Evidence map›Paper›PMID 35327427›Full record

ArticleBiomedicines2022

(Auto)Antibody Responses Shape Memory NK Cell Pool Size and Composition.

Cristina Capuano, Chiara Pighi, Simone Battella, Fabio Pulcinelli, Cristina Santoro, Antonietta Ferretti, Ombretta Turriziani, Davide De Federicis, Cinzia Fionda, Giuseppe Sciumè and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Nutrient transporter pattern in CD56Frontiers in immunology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Cristina CapuanoDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-6747-3836
Chiara PighiDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.
Simone BattellaDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.
Fabio PulcinelliDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.
Cristina SantoroHematology Division, Policlinico Umberto I, 00185 Rome, Italy.
Antonietta FerrettiHematology Division, Policlinico Umberto I, 00185 Rome, Italy.
Ombretta TurrizianiDepartment of Molecular Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0001-6400-9168
Davide De FedericisDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.
Cinzia FiondaDepartment of Molecular Medicine, Sapienza University of Rome, 00185 Roma, Italy.
Giuseppe SciumèDepartment of Molecular Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0003-0131-512X
Ricciarda GalandriniDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0003-2660-1456
Gabriella PalmieriDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-1467-1417
Sapienza University of Rome · ITPoliclinico Umberto I · IT

Funding

Sapienza University of Rome RP120172B81E572F; AR21916B74238026
6 · The paper itself

Abstract

In vivo establishment and long-term persistence of a heterogeneous memory or an adaptive NK cell pool represents a functional adaptation to human cytomegalovirus (HCMV) infection in humans. Memory NK cells are commonly identified by lack of the FcεRIγ signalling chain, variably associated to the preferential but not completely overlapping expression of the HLA-E receptor NKG2C and CD57 maturation marker. Although characterized by selective hyperresponsiveness to IgG stimulation, the impact of the CD16/antibody interaction in regulating the establishment/maintenance and size, and in determining the relative abundance of this population, is still under investigation. Memory NK cell subset ex vivo profile and in vitro responsiveness to CD16 stimulation was evaluated in HCMV

Indexed as

auto-antibodiesCD16HCMVimmune thrombocytopenia (ITP)memory natural killer (NK) cells

Identifiers

PMID35327427
PMCPMC8945707
OpenAlexW4220934371

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.