Evidence map›Paper›PMID 35327599›Full record

ArticleBiomolecules2022

Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets.

Geetali Pradhan, Jong Han Lee, Chia-Shan Wu, Hongying Wang, Ligen Lin, Taraka Donti, Brett H Graham, Arun S Rajan, Ashok Balasubramanyam, Susan L Samson and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Germline and conditional ghrelin knockout increases islet size.The Journal of clinical investigation · 2023
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Geetali PradhanUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Jong Han LeeUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Chia-Shan WuDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-6034-939X
Hongying WangDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Ligen LinUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-6799-5327
Taraka DontiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Brett H GrahamDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Arun S RajanDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Ashok BalasubramanyamDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Susan L SamsonDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8159-7093
Shaodong GuoDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0001-5126-731X
Yuxiang SunUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Baylor College of Medicine · USTexas A&M University · USChildren's Nutrition Research Center at Baylor College of Medicine · USHanseo University · KRUniversity of Macau · MO

Funding

Nutrient-sensing GHS-R in macrophage reprogramming and inflamm-agingR01AG064869 · NIA · TEXAS A&M AGRILIFE RESEARCH · PI SUN, YUXIANG · 2019 to 2023
$2.1M
The role of GHS-R in macrophage reprogramming during meta-inflammationR01DK118334 · NIDDK · TEXAS A&M AGRILIFE RESEARCH · PI SUN, YUXIANG · 2019 to 2022
$1.2M
NIA NIH HHS R01 AG064869NIDDK NIH HHS R01 DK118334
6 · The paper itself

Abstract

Ghrelin receptor, a growth hormone secretagogue receptor (GHS-R), is expressed in the pancreas. Emerging evidence indicates that GHS-R is involved in the regulation of glucose-stimulated insulin secretion (GSIS), but the mechanism by which GHS-R regulates GSIS in the pancreas is unclear. In this study, we investigated the role of GHS-R on GSIS in detail using global

Indexed as

Islets of LangerhansReceptors, GhrelinAnimalsGhrelinGlucoseInsulinInsulin SecretionMiceProto-Oncogene Proteins c-aktReceptor, InsulinGhrelinGlucoseInsulinProto-Oncogene Proteins c-aktReceptor, InsulinReceptors, Ghrelinglucose-stimulated insulin secretion (GSIS)glucose transporter 2 (Glut2)growth hormone secretagogue receptor (GHS-R)insulinisletspancreatic and duodenal homeobox 1 (Pdx1)

Identifiers

PMID35327599
PMCPMC8945998
OpenAlexW4221076057

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.