ReviewChildren (Basel, Switzerland)2022
Myopia Genetics and Heredity.
Review in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Orthokeratology in controlling myopia of children: a meta-analysis of randomized controlled trials.BMC ophthalmology · 2023Pooled it
- Evaluating the effect of a new myopia control spectacle lens among children in Israel: 24-month results.Eye (London, England) · 2026Trial
- Cross-tissue dual-omics analysis reveals molecular programs linked to myopia susceptibility and progression.Life science alliance · 2026Article
- Analysis of the Association Between Weight Status and Myopia in Children and Adolescents and Development of a Screening Model Based on Body Fat Percentage.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Progression of myopia among undergraduate students of Fatima Jinnah Medical University, Lahore.Pakistan journal of medical sciences · 2026Article
- Increased PRSS56 expression is a causal factor and therapeutic target for human axial high myopia.Cell research · 2026Article
- Model of naturally occurring refractive error (NORE) in mice.bioRxiv : the preprint server for biology · 2026Article
- Myopia as a Global Public Health Challenge a Narrative Review.Life (Basel, Switzerland) · 2026Review
- STudy of Atropine to Reduce (STAR) Myopia Progression in Children: 24-Month Results of a Randomized, Double-Masked, Vehicle-Controlled Trial of Atropine Sulfate 0.01% and 0.03.Ophthalmology and therapy · 2026Article
- Advances in the genetics of refractive errors: Contributions from the CREAM consortium.Acta ophthalmologica · 2026Review
- Unraveling the Heritability of Ocular Rigidity and Myopia-Related Traits: A Siblings-Based Study.Investigative ophthalmology & visual science · 2026Article
- Identification of a novel nonsense variant in ARR3 in a family with early-onset high myopia.Genes & genomics · 2026Article
- Association between ambient air pollution and prevalence of myopia in Korean men.BMC public health · 2026Article
- Robust and interpretable unit level causal inference in neural networks for pediatric myopia.NPJ digital medicine · 2026Article
- Mitochondria-Related Gene BDH1 Implicated in Myopia Risk via Methylation-Regulated Expression: An Integrative Summary-Data Mendelian Randomization Study.Translational vision science & technology · 2026Article
- Genetic Association Study Between Refractive Error-Related Genes and High Myopia in the Chinese Han Population.Journal of ophthalmology · 2026Article
- Associated factors of myopia in a Portuguese sample of adolescents: Parental history and school-related lifestyle.PloS one · 2026Article
- Myo-inflam: a mini review on inflammatory pathways driving scleral remodeling and axial elongation.Frontiers in immunology · 2026Review
- Multilevel Genetic and Functional Assessment of an ARR3 Frameshift Variant in Early-Onset High Myopia.International journal of genomics · 2026Article
- The prevalence and demographic profile of myopia among school children in Beirut City, Lebanon.BMC public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Myopia is the most common eye condition leading to visual impairment and is greatly influenced by genetics. Over the last two decades, more than 400 associated gene loci have been mapped for myopia and refractive errors via family linkage analyses, candidate gene studies, genome-wide association studies (GWAS), and next-generation sequencing (NGS). Lifestyle factors, such as excessive near work and short outdoor time, are the primary external factors affecting myopia onset and progression. Notably, besides becoming a global health issue, myopia is more prevalent and severe among East Asians than among Caucasians, especially individuals of Chinese, Japanese, and Korean ancestry. Myopia, especially high myopia, can be serious in consequences. The etiology of high myopia is complex. Prediction for progression of myopia to high myopia can help with prevention and early interventions. Prediction models are thus warranted for risk stratification. There have been vigorous investigations on molecular genetics and lifestyle factors to establish polygenic risk estimations for myopia. However, genes causing myopia have to be identified in order to shed light on pathogenesis and pathway mechanisms. This report aims to examine current evidence regarding (1) the genetic architecture of myopia; (2) currently associated myopia loci identified from the OMIM database, genetic association studies, and NGS studies; (3) gene-environment interactions; and (4) the prediction of myopia via polygenic risk scores (PRSs). The report also discusses various perspectives on myopia genetics and heredity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.