Evidence mapPaperPMID 35328045Full record

ArticleGenes2022

Pleiotropic Effects of Common and Rare

Kuan-Hung Yeh, Lung-An Hsu, Ming-Sheng Teng, Semon Wu, Hsin-Hua Chou, Yu-Lin Ko

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Prevalence ofJournal of obesity · 2023
    Article
  11. Pleiotropic Effects ofInternational journal of molecular sciences · 2022
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kuan-Hung YehCardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
Lung-An HsuThe First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 33305, Taiwan.ORCID 0000-0002-0012-2804
Ming-Sheng TengDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.ORCID 0000-0003-4140-5699
Semon WuDepartment of Life Science, Chinese Culture University, Taipei 11114, Taiwan.
Hsin-Hua ChouCardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
Yu-Lin KoCardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.ORCID 0000-0002-8218-6827
Tzu Chi University · TWChang Gung University · TWChinese Culture University · TWTaipei Tzu Chi Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe common non-synonymous mutation of the glucokinase regulator (

objectiveThis study aimed to identify whether other

methodsIn total, 81,097 Taiwan Biobank participants were enrolled for the regional plot association studies and candidate variant analysis of the region around the

resultsThe initial candidate variant approach showed the significant association of the rs1260326 genotypes with multiple phenotypes. Regional plot association analysis of the

conclusionIn addition to the rs1260326 variant, low-frequency and rare

Indexed as

Adaptor Proteins, Signal TransducingCardiovascular DiseasesMetabolic SyndromeAlbuminsBlood GlucoseGenetic PleiotropyHumansMutationPhenotypePolymorphism, Single NucleotideTriglyceridesAdaptor Proteins, Signal TransducingAlbuminsBlood GlucoseGCKR protein, humanTriglyceridesexonic mutationGCKR genepleiotropic effectserum albumin levelserum triglyceride level

Identifiers

PMID35328045
PMCPMC8951277
OpenAlexW4221080153

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.