Evidence map›Paper›PMID 35328429›Full record

ReviewInternational journal of molecular sciences2022

Exploring Pharmacological Functions of Alternatively Spliced Variants of the Mu Opioid Receptor Gene,

Wenjian Kang, Shan Liu, Jin Xu, Anna Abrimian, Ayma F Malik, Raymond Chien, Adejuyigbe Adaralegbe, Akwasi Amponsah, Luca Cartegni, John Pintar and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Alternative splicing in addiction.Current opinion in genetics & development · 2025
    Review
  4. Interactive effects of morphine and the HIV integrase inhibitor, cabotegravir, in male and female mice.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wenjian KangDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Shan LiuDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Jin XuDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Anna AbrimianDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Ayma F MalikDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Raymond ChienDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Adejuyigbe AdaralegbeDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0000-0002-6300-9235
Akwasi AmponsahDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Luca CartegniDepartment of Chemical Biology, Ernest Mario School of Pharmacy Rutgers University, Piscataway, NJ 08854, USA.
John PintarDepartment of Neuroscience & Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Ying-Xian PanDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Rutgers, The State University of New Jersey · US

Funding

Arylepoxamides: A new class of potent, safer analgesicsUG3DA048379 · NIDA · SLOAN-KETTERING INST CAN RESEARCH · PI PAN, YING-XIAN · 2019 to 2021
$6.8M
PHARMACOLOGY OF OPIOID RECEPTOR SUBTYPESR01DA007242 · NIDA · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PAN, YING-XIAN · 1991 to 2022
$6.0M
Characterizing exon 11 promoter of the mu opioid receptor gene, OPRMR01DA013997 · NIDA · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PAN, YING-XIAN · 2002 to 2012
$3.3M
Alternative pre-mRNA splicing of mu opioid receptor gene and mu opioid actionsR01DA042888 · NIDA · SLOAN-KETTERING INST CAN RESEARCH · PI PAN, YING-XIAN · 2017 to 2021
$1.9M
Exploring functions of mu opioid receptor carboxyl termini by gene targetingR21DA029244 · NIDA · SLOAN-KETTERING INST CAN RESEARCH · PI PAN, YING-XIAN · 2010 to 2011
$522k
National Institute of Health DA013997; DA029244; DA042888; DA048379; DA007242; DA09040NIDA NIH HHS R01 DA007242NIDA NIH HHS R01 DA013997NIDA NIH HHS R01 DA042888NIDA NIH HHS R21 DA029244NIDA NIH HHS UG3 DA048379
6 · The paper itself

Abstract

The mu opioid receptor has a distinct place in the opioid receptor family, since it mediates the actions of most opioids used clinically (e.g., morphine and fentanyl), as well as drugs of abuse (e.g., heroin). The single-copy mu opioid receptor gene,

Indexed as

Analgesics, OpioidReceptors, Opioid, muAlternative SplicingAnimalsMiceModels, AnimalMorphineAnalgesics, OpioidMorphineReceptors, Opioid, mualternative splicinganimal modelgene targetingmu opioid receptoropioidOPRM1

Identifiers

PMID35328429
PMCPMC8950057
OpenAlexW4220902873

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.