Evidence map›Paper›PMID 35328530›Full record

ArticleInternational journal of molecular sciences2022

The Protective Effect of a Unique Mix of Polyphenols and Micronutrients against Neurodegeneration Induced by an In Vitro Model of Parkinson's Disease.

Francesca Pacifici, Chiara Salimei, Donatella Pastore, Gina Malatesta, Camillo Ricordi, Giulia Donadel, Alfonso Bellia, Valentina Rovella, Marco Tafani, Enrico Garaci and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Francesca PacificiDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Chiara SalimeiDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-1649-0417
Donatella PastoreDepartment of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy.
Gina MalatestaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
Camillo RicordiCell Transplant Center, Diabetes Research Institute, School of Medicine, University of Miami Miller, Miami, FL 33136, USA.
Giulia DonadelDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-2454-5940
Alfonso BelliaDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Valentina RovellaDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-3311-486X
Marco TafaniDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-7128-810X
Enrico GaraciDepartment of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy.
Manfredi TesauroDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Davide LauroDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-8597-4415
Nicola Di DanieleDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0001-7671-0015
David Della-MorteDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
University of Rome Tor Vergata · ITSan Raffaele University of Rome · ITSapienza University of Rome · ITUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is second-most common disabling neurological disorder worldwide, and unfortunately, there is not yet a definitive way to prevent it. Polyphenols have been widely shown protective efficacy against various PD symptoms. However, data on their effect on physio-pathological mechanisms underlying this disease are still lacking. In the present work, we evaluated the activity of a mixture of polyphenols and micronutrients, named A5

Indexed as

Parkinson DiseaseAnimalsDisease Models, AnimalDopaminergic NeuronsMiceMicronutrientsOxidopaminePolyphenolsMicronutrientsOxidopaminePolyphenolsinflammationoxidative stressParkinson’s diseasepolyphenolsSIRT1

Identifiers

PMID35328530
PMCPMC8955775
OpenAlexW4220668884

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.