Evidence map›Paper›PMID 35328827›Full record

ArticleInternational journal of molecular sciences2022

Brain Cholesterol Biosynthetic Pathway Is Altered in a Preclinical Model of Fragile X Syndrome.

Martina Parente, Claudia Tonini, Valeria Buzzelli, Emilia Carbone, Viviana Trezza, Valentina Pallottini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Martina ParenteDepartment of Science, Roma Tre University, Viale Marconi 446, 00146 Rome, Italy.ORCID 0000-0002-9135-567X
Claudia ToniniDepartment of Science, Roma Tre University, Viale Marconi 446, 00146 Rome, Italy.ORCID 0000-0002-9979-1142
Valeria BuzzelliDepartment of Science, Roma Tre University, Viale Marconi 446, 00146 Rome, Italy.
Emilia CarboneDepartment of Science, Roma Tre University, Viale Marconi 446, 00146 Rome, Italy.
Viviana TrezzaDepartment of Science, Roma Tre University, Viale Marconi 446, 00146 Rome, Italy.ORCID 0000-0002-3922-6045
Valentina PallottiniDepartment of Science, Roma Tre University, Viale Marconi 446, 00146 Rome, Italy.ORCID 0000-0003-2511-6168
Roma Tre University · IT

Funding

Jerome Lejeune Foundation Research 1674Ministry of Education, Universities and Research 2017SXEXT5Miur ARTICOLO 1, COMMI 314-337 LEGGE 232/2016Together Strong NPC-Foundation 2/2020
6 · The paper itself

Abstract

Fragile X Syndrome (FXS) is the most frequent form of inherited X-linked pathology, associated with an intellectual and developmental disability, and currently considered the first monogenic cause of autism spectrum disorder (ASD). Low levels of total cholesterol reported in the serum of FXS patients, and evidence that FMRP targets a subset of mRNAs encoding proteins of lipid synthesis and transport suggests that the cholesterol metabolism impairments could be involved in FXS. Thus, the aim of the presented work was to investigate the modulations of the cholesterol biosynthetic pathway and its end-products in a recently developed

Indexed as

Autism Spectrum DisorderFragile X SyndromeAnimalsBiosynthetic PathwaysBrainCholesterolFragile X Messenger Ribonucleoprotein 1RatsCholesterolFmr1 protein, ratFragile X Messenger Ribonucleoprotein 13-Hydroxy 3-methylglutaryl Coenzyme A reductasebraincholesterolFmr1-Δexon 8 ratFragile X Syndromeliverlow-density lipoprotein receptorplasmaprenylated proteins

Identifiers

PMID35328827
PMCPMC8955806
OpenAlexW4220960290

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.