Evidence mapPaperPMID 35330559Full record

ArticleBalkan medical journal2022

Inhibiting miR-182-3p Alleviates Gestational Diabetes Mellitus by Improving Insulin Resistance in Skeletal Muscle.

Jinghong Rao, Youfang Chen, Jingying Huang, Ruoying Wu, Zhenzhu Dong, Yuling Gao, Xuan Chen

Open access · diamondAbstract read
In one paragraph

Article in Balkan medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jinghong RaoDepartment of Obstetrics and Gynecology Quanzhou First Hospital Affiliated to Fujian Medical University, Fuzhou, China.ORCID 0000-0002-6275-0929
Youfang ChenDepartment of Clinical Medicine Quanzhou Medical College, Fuzhou, China.ORCID 0000-0002-5908-2325
Jingying HuangDepartment of Obstetrics and Gynecology Quanzhou First Hospital Affiliated to Fujian Medical University, Fuzhou, China.ORCID 0000-0003-1530-1431
Ruoying WuDepartment of Obstetrics and Gynecology Quanzhou First Hospital Affiliated to Fujian Medical University, Fuzhou, China.ORCID 0000-0001-6836-6568
Zhenzhu DongDepartment of Obstetrics and Gynecology Quanzhou First Hospital Affiliated to Fujian Medical University, Fuzhou, China.ORCID 0000-0002-3453-7545
Yuling GaoDepartment of Obstetrics and Gynecology Quanzhou First Hospital Affiliated to Fujian Medical University, Fuzhou, China.ORCID 0000-0003-3018-4122
Xuan ChenDepartment of Obstetrics and Gynecology Quanzhou First Hospital Affiliated to Fujian Medical University, Fuzhou, China.ORCID 0000-0001-9268-5665
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases occurring during pregnancy. MiR-182-3p participates in a variety of physiological processes such as cell proliferation, apoptosis, differentiation, and migration5, but its role in GDM is largely unknown. Aims: To investigate the relationship between miRNA-182-3p and GDM and explore a potential therapeutic strategy for GDM. Study Design: Animal experimentation. Methods: To evaluate the effect of miRNA182-3p in GDM, mice were separated as negative control (NC), miRNA-182-3p mimic or miRNA-182-3p inhibitor, and miRNAs were administered intraperitoneally. Additionally, miRNA-182-3p mimic or miRNA-182-3p inhibitor was transfected into C2C12 cells to evaluate glucose metabolism and insulin-related pathways. Results: The miR-182-3p mimic accelerated GDM, which was effectively reversed by the inhibitor in GDM mice ( Conclusion: Inhibiting miR-182-3p effectively alleviated the development of GDM through INSR1, suggesting a potential therapeutic strategy for GDM.

Indexed as

Diabetes, GestationalInsulin ResistanceAnimalsFemaleHumansInsulinMiceMicroRNAsMuscle, SkeletalPregnancyInsulinMicroRNAsMirn182 microRNA, humanMirn182 microRNA, mouse

Identifiers

PMID35330559
PMCPMC8941230
OpenAlexW4206333475

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.