ArticleNature ecology & evolution2022
Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas.
Article in Nature ecology & evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Relationship Value, Emotion, and Uncertainty Shape Conflict-Resolution Communication in a Wild Primate.Annals of the New York Academy of Sciences · 2026Article
- Diverse anelloviruses identified in wild geladas (Theropithecus gelada).Archives of virology · 2026Article
- Benchmarking imputation accuracy in the presence or absence of a reference panel.Molecular biology and evolution · 2026Article
- Retrotransposition Events Shape the Evolution of the Ataxin-3 Gene Family in Primates.Genome biology and evolution · 2026Article
- Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Early-life infection dynamics and genomic diversity of adenoviruses in a wild primate (Microbial genomics · 2025Article
- A Reassessment of the Genomic Ancestry of the World's Largest Captive Baboon Colony.American journal of primatology · 2025Article
- Transcriptome analysis of five-toed jerboa organs reveals high-altitude adaptation mechanisms.BMC genomics · 2025Article
- Phylogenetics and genomic variation of Hepatocystis isolated from shotgun sequencing of wild primate hosts.PLoS pathogens · 2025Article
- Cost-effective solutions for high-throughput enzymatic DNA methylation sequencing.PLoS genetics · 2025Article
- Selection on the vascular-remodelingEvolution letters · 2025Article
- Whole Genome Analysis Reveals Evolutionary History and Introgression Events in Bale Monkeys.Genes · 2024Article
- Physiological and Genetic Basis of High-Altitude Indigenous Animals' Adaptation to Hypoxic Environments.Animals : an open access journal from MDPI · 2024Review
- Comparative DNA methylation reveals epigenetic adaptation to high altitude in snub-nosed monkeys.Zoological research · 2024Article
- Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep.Genomics, proteomics & bioinformatics · 2024Article
- Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors.Nature ecology & evolution · 2024Article
- Hypoxia Inducible Factor pathway proteins in high-altitude mammals.Trends in biochemical sciences · 2024Review
- Glutathione Non-Covalent Binding Sites on Hemoglobin and Major Glutathionylation Target betaCys93 Are Conservative among Both Hypoxia-Sensitive and Hypoxia-Tolerant Mammal Species.International journal of molecular sciences · 2023Article
- Potential changes in the extent of suitable habitats for geladas (Theropithecus gelada) in the Anthropocene.BMC ecology and evolution · 2023Article
- Assessing the recovery of Y chromosome microsatellites with population genomic data using Papio and Theropithecus genomes.Scientific reports · 2023Article
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Authors and funding
29 authors at 18 institutions in 7 countries.
Funding
Abstract
Primates have adapted to numerous environments and lifestyles but very few species are native to high elevations. Here we investigated high-altitude adaptations in the gelada (Theropithecus gelada), a monkey endemic to the Ethiopian Plateau. We examined genome-wide variation in conjunction with measurements of haematological and morphological traits. Our new gelada reference genome is highly intact and assembled at chromosome-length levels. Unexpectedly, we identified a chromosomal polymorphism in geladas that could potentially contribute to reproductive barriers between populations. Compared with baboons at low altitude, we found that high-altitude geladas exhibit significantly expanded chest circumferences, potentially allowing for greater lung surface area for increased oxygen diffusion. We identified gelada-specific amino acid substitutions in the alpha-chain subunit of adult haemoglobin but found that gelada haemoglobin does not exhibit markedly altered oxygenation properties compared with lowland primates. We also found that geladas at high altitude do not exhibit elevated blood haemoglobin concentrations, in contrast to the normal acclimatization response to hypoxia in lowland primates. The absence of altitude-related polycythaemia suggests that geladas are able to sustain adequate tissue-oxygen delivery despite environmental hypoxia. Finally, we identified numerous genes and genomic regions exhibiting accelerated rates of evolution, as well as gene families exhibiting expansions in the gelada lineage, potentially reflecting altitude-related selection. Our findings lend insight into putative mechanisms of high-altitude adaptation while suggesting promising avenues for functional hypoxia research.
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