ArticleActa neuropathologica2022
Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood.
Article in Acta neuropathologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- The Amyloid Plaque Proteomes of Alzheimer's Disease and Mild Cognitive Impairment.Research square · 2026Article
- Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain.Acta neuropathologica communications · 2026Article
- Identification of MFN2 and NCL as cardiac biomarkers for post-mortem diagnosis of atypical electrocution death.International journal of legal medicine · 2026Article
- Incremental Prognostic Value of Hippocampal Metabolic Activity for Sudden Cardiac Death in Patients With Heart Failure With Reduced Ejection Fraction.Journal of the American Heart Association · 2025Article
- Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history.Acta neuropathologica · 2024Article
- Differences in the cerebral amyloid angiopathy proteome in Alzheimer's disease and mild cognitive impairment.Acta neuropathologica · 2024Article
- Video Analyses of Sudden Unexplained Deaths in Toddlers.Neurology · 2024Article
- Similar brain proteomic signatures in Alzheimer's disease and epilepsy.Acta neuropathologica · 2024Article
- Unexplained and Unexpected Pediatric Deaths: Forensic Review and New Perspectives.Diagnostics (Basel, Switzerland) · 2023Review
- Metabolomic, proteomic, and transcriptomic changes in adults with epilepsy on modified Atkins diet.Epilepsia · 2023Article
- Localized proteomic differences in the choroid plexus of Alzheimer's disease and epilepsy patients.Frontiers in neurology · 2023Article
- Neurodevelopmental disorders: 2023 update.Free neuropathology · 2023Article
- Sudden unexpected death in epilepsy.Current opinion in neurology · 2022Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Sudden unexplained death in childhood (SUDC) is death of a child over 1 year of age that is unexplained after review of clinical history, circumstances of death, and complete autopsy with ancillary testing. Multiple etiologies may cause SUDC. SUDC and sudden unexpected death in epilepsy (SUDEP) share clinical and pathological features, suggesting some similarities in mechanism of death and possible abnormalities in hippocampus and cortex. To identify molecular signaling pathways, we performed label-free quantitative mass spectrometry on microdissected frontal cortex, hippocampal dentate gyrus (DG), and cornu ammonis (CA1-3) in SUDC (n = 19) and pediatric control cases (n = 19) with an explained cause of death. At a 5% false discovery rate (FDR), we found differential expression of 660 proteins in frontal cortex, 170 in DG, and 57 in CA1-3. Pathway analysis of altered proteins identified top signaling pathways associated with activated oxidative phosphorylation (p = 6.3 × 10
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