ArticleNutrients2022
Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003-2006 Surveys.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Exploring the association between vitamin C intake and gingival bleeding tendency in healthy, non‑deficient young adults.Journal of periodontology · 2026Article
- Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database.Frontiers in medicine · 2026Article
- Red blood cell distribution width and mortality in chronic obstructive pulmonary disease patients with acute respiratory failure: a retrospective study.Scientific reports · 2025Article
- The Community Prevalence of Vitamin C Deficiency and Inadequacy-How Does Australia Compare With Other Nations? A Scoping Review.Health science reports · 2025Review
- Vitamin C in Cardiovascular Disease: From Molecular Mechanisms to Clinical Evidence and Therapeutic Applications.Antioxidants (Basel, Switzerland) · 2025Review
- Machine learning prediction of preterm birth in women under 35 using routine biomarkers in a retrospective cohort study.Scientific reports · 2025Article
- Prospective Associations of Dietary Antioxidant Vitamin Intake and 8-Year Risk of Elevated SerumNutrients · 2025Article
- Association between the hemoglobin-to-red cell distribution width ratio and three-month unfavorable outcome in older acute ischemic stroke patients: a prospective study.Frontiers in neurology · 2025Article
- Development and validation of a multidimensional predictive model for 28-day mortality in ICU patients with bloodstream infections: a cohort study.Frontiers in cellular and infection microbiology · 2025Article
- Anti-inflammatory activity of the phenol rich fraction of Garcinia pedunculata Roxb (ex. Buch Ham): an in vitro and in vivo study.Inflammopharmacology · 2024Article
- Association between dietary vitamin C and abdominal aortic calcification among the US adults.Nutrition journal · 2023Article
- Precision Nutrition: The Hype Is Exceeding the Science and Evidentiary Standards Needed to Inform Public Health Recommendations for Prevention of Chronic Disease.Annual review of nutrition · 2023Review
- Subclinical Vitamin C Plasma Levels Associated with Increased Risk of CAD Diagnosis via Inflammation: Results from the NHANES 2003-2006 Surveys.Nutrients · 2023Article
- Article
- The cross-sectional relationship between vitamin C and high-sensitivity C-reactive protein levels: insights from NHANES database.Frontiers in nutrition · 2023Article
- Association between serum vitamin C and HPV infection in American women: a cross-sectional study.BMC women's health · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although undisputed for its anti-inflammatory and immune system boosting properties, vitamin C remains an inconsistently investigated nutrient in the United States. However, subclinical inadequacies may partly explain increased inflammation and decreased immune function within the population. This secondary analysis cross-sectional study used the 2003-2006 NHANES surveys to identify more clearly the association between plasma vitamin C and clinical biomarkers of acute and chronic inflammation C-reactive protein (CRP) and red cell distribution width (RDW). From plasma vitamin C levels separated into five defined categories (deficiency, hypovitaminosis, inadequate, adequate, and saturating), ANOVA tests identified significant differences in means in all insufficient vitamin C categories (deficiency, hypovitaminosis, and inadequate) and both CRP and RDW in 7607 study participants. There were also statistically significant differences in means between sufficient plasma vitamin C levels (adequate and saturating categories) and CRP. Significant differences were not identified between adequate and saturating plasma vitamin C levels and RDW. Although inadequate levels of vitamin C may not exhibit overt signs or symptoms of deficiency, differences in mean levels identified between inflammatory biomarkers suggest a closer examination of those considered at risk for inflammatory-driven diseases. Likewise, the subclinical levels of inflammation presented in this study provide evidence to support ranges for further clinical inflammation surveillance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.