Evidence map›Paper›PMID 35335296›Full record

ArticleMolecules (Basel, Switzerland)2022

Thiazolidin-4-Ones as Potential Antimicrobial Agents: Experimental and In Silico Evaluation.

Christophe Tratrat, Anthi Petrou, Athina Geronikaki, Marija Ivanov, Marina Kostić, Marina Soković, Ioannis S Vizirianakis, Nikoleta F Theodoroula, Michelyne Haroun

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christophe TratratDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.ORCID 0000-0001-9064-1706
Anthi PetrouDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-8587-2710
Athina GeronikakiDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-9894-7777
Marija IvanovMycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stankovic-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000 Belgrade, Serbia.ORCID 0000-0002-2480-5490
Marina KostićMycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stankovic-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000 Belgrade, Serbia.ORCID 0000-0001-8717-6495
Marina SokovićMycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stankovic-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000 Belgrade, Serbia.ORCID 0000-0002-7381-756X
Ioannis S VizirianakisLaboratory of Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0003-1459-9774
Nikoleta F TheodoroulaLaboratory of Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Michelyne HarounDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

Funding

Deanship of Scientific Research of King Faisal University 160006the Serbian Ministry of Education, Science and Technological Development 451-03-9/2021-14/200007
6 · The paper itself

Abstract

Herein, we report computational and experimental evaluations of the antimicrobial activity of twenty one 2,3-diaryl-thiazolidin-4-ones. All synthesized compounds exhibited an antibacterial activity against six Gram-positive and Gram-negative bacteria to different extents. Thus, the MIC was in the range of 0.008-0.24 mg/mL, while the MBC was 0.0016-0.48 mg/mL. The most sensitive bacterium was

Indexed as

Anti-Infective AgentsGram-Negative BacteriaAnti-Bacterial AgentsEscherichia coliGram-Positive BacteriaHumansMicrobial Sensitivity TestsMolecular Docking SimulationStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsAnti-Infective AgentsantibacterialantifungalCYP51dockingmicrodilution methodMRC-5MurBthiazolidine-4-one

Identifiers

PMID35335296
PMCPMC8954104

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.