Evidence map›Paper›PMID 35336768›Full record

ArticleBiology2022

Epidemiology of Hypothyroidism, Hyperthyroidism and Positive Thyroid Antibodies in the Croatian Population.

Ivana Strikić Đula, Nikolina Pleić, Mirjana Babić Leko, Ivana Gunjača, Vesela Torlak, Dubravka Brdar, Ante Punda, Ozren Polašek, Caroline Hayward, Tatijana Zemunik

Open access · goldAbstract read
In one paragraph

Article in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

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  15. Innate Immunity in Autoimmune Thyroid Disease during Pregnancy.International journal of molecular sciences · 2023
    Review
  16. The Thyroid Hormone Axis and Female Reproduction.International journal of molecular sciences · 2023
    Review
  17. Article
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ivana Strikić ĐulaHealth Center Sibenik, 22 000 Sibenik, Croatia.
Nikolina PleićDepartment of Medical Biology, School of Medicine, University of Split, 21 000 Split, Croatia.ORCID 0000-0001-5672-871X
Mirjana Babić LekoDepartment of Medical Biology, School of Medicine, University of Split, 21 000 Split, Croatia.ORCID 0000-0003-4223-4190
Ivana GunjačaDepartment of Medical Biology, School of Medicine, University of Split, 21 000 Split, Croatia.ORCID 0000-0002-7056-6443
Vesela TorlakDepartment of Nuclear Medicine, University Hospital of Split, 21 000 Split, Croatia.
Dubravka BrdarDepartment of Nuclear Medicine, University Hospital of Split, 21 000 Split, Croatia.
Ante PundaDepartment of Nuclear Medicine, University Hospital of Split, 21 000 Split, Croatia.
Ozren PolašekDepartment of Public Health, School of Medicine, University of Split, 21 000 Split, Croatia.ORCID 0000-0002-5765-1862
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0002-9405-9550
Tatijana ZemunikDepartment of Medical Biology, School of Medicine, University of Split, 21 000 Split, Croatia.ORCID 0000-0001-8120-2891
University of Split · HRInstitute of Genetics and Cancer · GBŠibenik University of Applied Sciences · HR

Funding

Croatian Science Foundation 2593Medical Research Council MC_UU_00007/10
6 · The paper itself

Abstract

Thyroid dysfunction appears to be the leading endocrine disorder. We conducted a cross-sectional study on 4402 individuals from three Croatian cohorts. The aim of this study was to analyse the prevalence of diagnosed and undiagnosed hypothyroidism, hyperthyroidism (subclinical and clinical) and positive thyroid antibodies in the Croatian population. The results of the study indicated that 17.6% of participants were euthyroid with positive antibodies. The prevalence of clinical and subclinical hypothyroidism was 3% and 7.4%, respectively, while the prevalence of clinical and subclinical hyperthyroidism was 0.2% and 1.1%, respectively. Among them, 92.6% subclinical hypothyroid, 93.9% clinical hypothyroid, 83% subclinical hyperthyroid and 71.4% clinical hyperthyroid participants were undiagnosed. Finally, the prevalence of undiagnosed subclinical and clinical hypothyroidism in our population was 6.9% and 2.8%, respectively, while the prevalence of undiagnosed subclinical and clinical hyperthyroidism was 0.9% and 0.1%, respectively. Women showed a higher prevalence of thyroid disorders; 1.57 times higher odds of euthyroidism with positive antibodies, 2.1 times higher odds of subclinical hyperthyroidism, 2.37 times higher odds of clinical hypothyroidism and 1.58 times higher odds of subclinical hypothyroidism than men. These results indicate an extremely high proportion of undiagnosed cases, and therefore require investments in a prevention programme.

Indexed as

epidemiologyhyperthyroidismhypothyroidismprevalenceundiagnosed cases

Identifiers

PMID35336768
PMCPMC8945477
OpenAlexW4214933600

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.