Evidence map›Paper›PMID 35338544›Full record

ArticleHead & neck2022

The association between inflammatory biomarkers and statin use among patients with head and neck squamous cell carcinoma.

Kayla R Getz, Emily Bellile, Katie R Zarins, Steven B Chinn, Jeremy M G Taylor, Laura S Rozek, Gregory T Wolf, Alison M Mondul

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kayla R GetzDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.ORCID 0000-0001-5552-044X
Emily BellileDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Katie R ZarinsDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Steven B ChinnDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
Jeremy M G TaylorDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Laura S RozekDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.ORCID 0000-0001-6731-7000
Gregory T WolfDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
Alison M MondulDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Statistical Methods for Cancer BiomarkersR01CA129102 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GHOSH, DEBASHIS, TAYLOR, JEREMY M.G. · 2009 to 2021
$3.3M
NCI NIH HHS P30 CA046592NCI NIH HHS P30CA046592NCI NIH HHS R01 CA129102NCI NIH HHS R01CA129102
6 · The paper itself

Abstract

backgroundTumor-infiltrating lymphocytes (TILs) and cytokines are associated with prognosis among patients with head and neck squamous cell carcinoma (HNSCC). Statins (cholesterol-lowering drugs) may improve HNSCC prognosis, particularly in human papillomavirus (HPV)-positive cases, but the mechanism remains unclear.

methodsStatin use was collected from medical records for HNSCC cases (2008-2014). TILs were counted in tumor tissue, and a total weighted score (TILws) was created. Cytokines were measured in blood. The associations between statins and biomarkers were estimated using logistic (biomarker categories: <median, ≥median) and linear regression models (log-transformed continuous biomarkers) adjusted for age, smoking, and comorbidities.

resultsWe observed a positive association between statins and TILs among HPV-positive patients (TILws odds ratio [OR] = 2.80; 95% CI = 1.03-7.61), but no association among HPV-negative patients. We observed no association between statins and cytokines.

conclusionsStatins may influence TILs in HPV-positive patients. This may be the mechanism through which they improve prognosis in HPV-positive HNSCC patients.

Indexed as

Head and Neck NeoplasmsHydroxymethylglutaryl-CoA Reductase InhibitorsPapillomavirus InfectionsBiomarkers, TumorCytokinesHumansPapillomaviridaePrognosisSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorCytokinesHydroxymethylglutaryl-CoA Reductase Inhibitorsbiomarkersepidemiologyhead and neck cancerHPVinflammation

Identifiers

PMID35338544
PMCPMC9088158
OpenAlexW4221137008

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.