ArticleThe Journal of pharmacology and experimental therapeutics2022
L-Arginine Enhances the Effects of Cardiac Rehabilitation on Physical Performance: New Insights for Managing Cardiovascular Patients During the COVID-19 Pandemic.
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Article in The Journal of pharmacology and experimental therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Beneficial effects of L-Arginine in patients hospitalized for COVID-19: New insights from a randomized clinical trial.Pharmacological research · 2023Trial
- L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults.Frontiers in cardiovascular medicine · 2022Trial
- L-Arginine and Nitric Oxide in Vascular Regulation-Experimental Findings in the Context of Blood Donation.Nutrients · 2025Review
- Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance.GeroScience · 2024Article
- Combining L-arginine and vitamin C improves physical frailty in hypertensive elders.European journal of internal medicine · 2024Article
- Exploring the role of CBLB in acute myocardial infarction: transcriptomic, microbiomic, and metabolomic analyses.Journal of translational medicine · 2024Article
- Dietary Supplements in Cardiovascular and Metabolic Diseases.Nutrients · 2024Article
- Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID.NPJ science of food · 2024Review
- Dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional study.BMC endocrine disorders · 2024Article
- Effects of moderate caffeine intake in athletes.European journal of internal medicine · 2024Article
- The Effectiveness of L-arginine in Clinical Conditions Associated with Hypoxia.International journal of molecular sciences · 2023Review
- Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19.The Journal of pharmacology and experimental therapeutics · 2023Article
- Levels of depressive symptoms in cardiac patients attending cardiac rehabilitation with a history of depression: pre Covid-19 and Covid-19 period comparison.BMC cardiovascular disorders · 2022Article
- Effects of Cardiac Rehabilitation in Cardiopulmonary Fitness with High-Risk Myocardial Infarction.Healthcare (Basel, Switzerland) · 2022Article
- Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey.Pharmacological research · 2022Article
- Current Evidence of Watermelon (Nutrients · 2022Review
- Mobility Status Plays an Important Role in the Risk of Cardiovascular Rehospitalizations in Patients with Heart Failure Undergoing Cardiac Rehabilitation: A Retrospective Cohort Study.Journal of personalized medicine · 2022Article
- Hyperglycemia and Physical Impairment in Frail Hypertensive Older Adults.Frontiers in endocrinology · 2022Article
- Clinical Perspectives on Cardiac Rehabilitation After Heart Failure in Elderly Patients with Frailty: A Narrative Review.Therapeutics and clinical risk management · 2022Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Pasquale MoneDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Raffaele IzzoDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Giuseppe MarazziDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Maria Virginia ManziDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Paola GalloDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Giuseppe CampolongoDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Luca CacciottiDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Domenico TartagliaDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Giuseppe CaminitiDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Fahimeh VarzidehDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Gaetano SantulliDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.) gaetano.santulli@einsteinmed.edu.
Valentina TrimarcoDepartments of Medicine (Cardiology) and Molecular Pharmacology - Wilf Family Cardiovascular Research Institute, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Neuroimmunology and Inflammation, Einstein-Sinai Diabetes Research Center, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York (P.M., F.V., G.S.); Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.); Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy (V.T.), New York, New York (P.M., F.V., G.S.); University of Naples Federico II, Naples, Italy (R.I., M.V.M., P.G., G.S., V.T.); IRCCS San Raffaele, Rome, Italy (G.M., G.Cami.); San Carlo di Nancy Hospital, Rome, Italy (G.Camp.); Madre Giuseppina Vannini Hospital, Rome, Italy (L.C.); and ASL AV, Avellino, Italy (D.T.).
Feinstein Institute for Medical Research · USVita-Salute San Raffaele University · ITAlbert Einstein College of Medicine · USIstituto di Ricovero e Cura a Carattere Scientifico San RaffaeleUniversity of Naples Federico II · IT
Funding
REGULATION OF THE INSULIN RECEPTOR KINASER01DK033823 · NIDDK · UNIVERSITY OF IOWA · PI KURLAND, IRWIN JACK, PESSIN, JEFFREY E. · 1986 to 2022
$6.7MModulation of Mitofusin Activity to Treat Heart DiseaseR01HL159062 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KITSIS, RICHARD N · 2021 to 2024
$2.6MFunctional role of IP3 receptors in the regulation of cardiac myofibroblastsR01HL146691 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SANTULLI, GAETANO · 2019 to 2023
$2.1MMechanisms of cardiovascular diseaseT32HL144456 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Carlos Jose Rodriguez, Nicholas E Sibinga · 2019 to 2026
$1.9MBeta Cell Intracellular Calcium and DiabetesR01DK123259 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SANTULLI, GAETANO · 2020 to 2023
$1.7MDeciphering the enigmatic role of IGF-1 signaling in cognitive decline and Alzheimer's diseaseR56AG066431 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI GANDY, SAMUEL E., HUFFMAN, DEREK MAJOR · 2020 to 2020
$858kNHLBI NIH HHS R01 HL146691NHLBI NIH HHS R01 HL159062NHLBI NIH HHS T32 HL144456NIA NIH HHS R56 AG066431NIDDK NIH HHS R01 DK033823NIDDK NIH HHS R01 DK123259
Abstract
Cardiac rehabilitation (CR) following acute myocardial infarction (AMI) improves physical capacities and decreases hospitalizations and cardiovascular mortality. L-arginine is the substrate used by nitric oxide (NO) synthase to generate NO and it has been shown to exert its beneficial effects on endothelium driving vasodilatation, reducing inflammation, and ameliorating physical function. We hypothesized that L-arginine could enhance physical capacities in patients who underwent CR after AMI. We designed a study aimed to assess the effects of L-arginine administration on the physical capacity of patients who underwent coronary revascularization after AMI. The trial was carried out amid the COVID-19 pandemic. Patients were assigned, with a 2:1 ratio, to add to their standard therapy one bottle containing 1.66 g of L-arginine or one bottle of identical aspect apart from not containing L-arginine, twice a day orally for 3 weeks. Patients performed a 6-minute walking test (6MWT), and their Borg modified 0-10 rating of perceived exertion (BRPE) was assessed before starting and at the end of the treatment. Seventy-five patients receiving L-arginine, and 35 receiving placebo successfully completed the study. The 6MWT distance increased significantly in the L-arginine group compared with both baseline and placebo (
Indexed as
Cardiac RehabilitationCOVID-19Myocardial InfarctionArginineHeartHumansNitric Oxide SynthasePandemicsArginineNitric Oxide Synthase
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