Evidence map›Paper›PMID 35340661›Full record

ArticleOncoimmunology2022

Toll-like receptor agonist combinations augment mouse T-cell anti-tumor immunity via IL-12- and interferon ß-mediated suppression of immune checkpoint receptor expression.

Donghwan Jeon, Douglas G McNeel

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Toll-like receptor agonists as cancer vaccine adjuvants.Human vaccines & immunotherapeutics · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Donghwan JeonUniversity of Wisconsin Carbone Cancer Center, Madison, WI, USA.
Douglas G McNeelUniversity of Wisconsin Carbone Cancer Center, Madison, WI, USA.
University of Wisconsin Carbone Cancer Center · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Effective Anti-Tumor Vaccination - Targeting Checkpoint Regulation at the Time of T-cell ActivationR01CA219154 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MCNEEL, DOUGLAS G. · 2017 to 2021
$1.7M
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA219154
6 · The paper itself

Abstract

We previously found that activated CD8

Indexed as

CD8-Positive T-LymphocytesInterleukin-12Toll-Like ReceptorsAdjuvants, ImmunologicAnimalsImmune Checkpoint ProteinsInterferonsLigandsMiceProgrammed Cell Death 1 ReceptorToll-Like Receptor 1Toll-Like Receptor 3Toll-Like Receptor 9Adjuvants, ImmunologicImmune Checkpoint ProteinsInterferonsInterleukin-12LigandsProgrammed Cell Death 1 ReceptorToll-Like Receptor 1Toll-Like Receptor 3Toll-Like Receptor 9Toll-Like ReceptorsadjuvantIL-12Toll-like receptortumor vaccinetype 1 interferon

Identifiers

PMID35340661
PMCPMC8942433
OpenAlexW4225938744

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.