Evidence map›Paper›PMID 35343255›Full record

ArticleJournal of diabetes science and technology2023

Determining Losses in Jet Injection Subcutaneous Insulin Delivery: A Model-Based Approach.

Alexander D McHugh, J Geoffrey Chase, Jennifer L Knopp, Tony Zhou, Lui Holder-Pearson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes science and technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alexander D McHughCentre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.ORCID 0000-0001-7964-7082
J Geoffrey ChaseCentre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.ORCID 0000-0001-9989-4849
Jennifer L KnoppCentre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.ORCID 0000-0001-9343-3961
Tony ZhouCentre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.ORCID 0000-0002-3606-2698
Lui Holder-PearsonCentre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.
University of Canterbury · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAccurate, safe glycemic management requires reliable delivery of insulin doses. Insulin can be delivered subcutaneously for action over a longer period of time. Needle-free jet injectors provide subcutaneous (SC) delivery without requiring needle use, but the volume of insulin absorbed varies due to losses associated with the delivery method. This study employs model-based methods to determine the expected proportion of active insulin present from a needle-free SC dose.

methodsInsulin, C-peptide, and glucose assay data from a frequently sampled insulin-modified oral glucose tolerance test trial with 2U SC insulin delivery, paired with a well-validated metabolic model, predict metabolic outcomes for

resultsOptimal parameter identification suggests losses of up to 22% of the nominal 2U SC dose. The degree of loss varies between subjects and between trials on the same subject. Insulin fit accuracy improves where loss greater than 5% is identified, relative to where delivery loss is not modeled.

conclusionsModeling shows needle-free SC jet injection of a nominal dose of insulin does not necessarily provide metabolic action equivalent to total dose, and this availability significantly varies between trials. By quantifying and accounting for variability of jet injection insulin doses, better glycemic management outcomes using SC jet injection may be achieved.

Indexed as

InsulinInsulin, Regular, HumanAdultGlucose Tolerance TestHumansInjections, JetInjections, SubcutaneousInsulinInsulin, Regular, Humanhepatic clearanceidentificationidentification errorinsulin kineticsinsulin modifiedjet injectionOGTTsubcutaneous insulin

Identifiers

PMID35343255
PMCPMC10347999
OpenAlexW4221002288

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.