Evidence map›Paper›PMID 35343849›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Kidney stone formation in a novel murine model of polycystic kidney disease.

Heather A L Riddle, Shiqin Zhang, Feng Qian, James C Williams, Jason R Stubbs, Peter Stanley N Rowe, Stephen C Parnell

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Rare Case ofInternational medical case reports journal · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Heather A L RiddleThe Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0002-7733-1321
Shiqin ZhangThe Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.
Feng QianDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.ORCID 0000-0001-9595-9772
James C WilliamsDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0001-6665-6596
Jason R StubbsThe Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0003-4580-5745
Peter Stanley N RoweThe Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.
Stephen C ParnellThe Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0002-8422-1147
University of Kansas Medical Center · USIndiana University School of MedicineUniversity of Maryland, Baltimore · US

Funding

Polycystin Function Resource Development CoreU54DK126126 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Alan S Yu · 2020 to 2026
$5.8M
Impact of Phosphaturia on Renal Osteopontin Production and PKD ProgressionR01DK122212 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jason Stubbs, Kurt A Zimmerman · 2019 to 2026
$3.1M
The Molecular Mechanisms of Polycystin-1 Proteolytic Cleavage in Kidney Health and Polycystic Kidney DiseaseR01DK111611 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI QIAN, FENG · 2017 to 2021
$2.2M
Essential characterization of the Randall's plaque-overgrowth interfaceR01DK124776 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI WILLIAMS, JAMES C · 2020 to 2022
$713k
SkyScan 1172 High-resolution desk-top micro-CT systemS10RR023710 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI WILLIAMS, JAMES C · 2007 to 2007
$297k
The Molecular Mechanisms of Polycystin-1 Proteolytic Cleavage in Kidney Health and Polycystic Kidney DiseaseR56DK111611 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI QIAN, FENG · 2016 to 2016
$116k
NCRR NIH HHS S10 RR023710NIDDK NIH HHS R01 DK111611NIDDK NIH HHS R01 DK122212NIDDK NIH HHS R01 DK124776NIDDK NIH HHS R56 DK111611NIDDK NIH HHS U54 DK126126
6 · The paper itself

Abstract

Individuals with autosomal dominant polycystic kidney disease have a higher incidence of stone formation than the general population. However, there are no cystic animal models known to develop stones. Cystic mice compound heterozygous for hypomorphic

Indexed as

CystsKidney CalculiPolycystic Kidney, Autosomal DominantPolycystic Kidney DiseasesAnimalsCalciumCitratesDisease Models, AnimalHumansKidneyMicePhosphatesTRPP Cation ChannelsX-Ray MicrotomographyCalciumCitratesPhosphatesTRPP Cation Channelsautosomal dominant polycystic kidney diseasekidney stonesnephrolithiasispolycystic kidney diseasepolycystin-1

Identifiers

PMID35343849
PMCPMC9236864
OpenAlexW4221106737

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.