Evidence map›Paper›PMID 35345960›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562.

Nehad M El-Dydamony, Rana M Abdelnaby, Rasha Abdelhady, Omaima Ali, Mohamed I Fahmy, Rasha R Fakhr Eldeen, Amira A Helwa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. [High expression of CPNE3 correlates with poor long-term prognosis of gastric cancer by inhibiting cell apoptosisNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  5. Novel pyrazolo[3,4-RSC medicinal chemistry · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Nehad M El-DydamonyPharmaceutical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Egypt.
Rana M AbdelnabyPharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Rasha AbdelhadyPharmacology and Toxicology Department, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.
Omaima AliCell Line Unit, Egyptian Drug Authority (EDA), Cairo, Egypt.
Mohamed I FahmyPharmacology and Toxicology Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Rasha R Fakhr EldeenBiochemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Egypt.
Amira A HelwaPharmaceutical Organic Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Egypt.
Misr University for Science and Technology · EGHeliopolis University · EGEgyptian Government · EGFayoum University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel series of 4-(4-Methoxyphenyl)-2-(methylthio)pyrimidine-5-carbonitrile was developed linked to an aromatic moiety

Indexed as

Antineoplastic AgentsLeukemiaNitrilesPyrimidinesApoptosisCaspase 3Cyclin D1HumansK562 CellsMCF-7 CellsNF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAKT1 protein, humanAntineoplastic AgentsCASP3 protein, humanCaspase 3CCND1 protein, humanCyclin D1NF-kappa BNitrilesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPyrimidinesapoptosisbreast cancer (MCF-7)leukaemia (K562)PI3K/AKT pathwayPyrimidine-5-carbonitrile

Identifiers

PMID35345960
PMCPMC8967206
OpenAlexW4220660067

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.