Evidence map›Paper›PMID 35346266›Full record

ReviewFluids and barriers of the CNS2022

Non-coding RNAs in the regulation of blood-brain barrier functions in central nervous system disorders.

Ping Sun, Milton H Hamblin, Ke-Jie Yin

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fluids and barriers of the CNS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
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  6. Article
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  8. Article
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  10. Non-coding RNA-mediated gene regulation in Alzheimer's disease pathogenesis: molecular insights and emerging innovations.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Review
  11. Article
  12. Review
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  15. Article
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  17. Involvement of lncRNA in cancer diagnosis and prognosis and clinical implications.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Review
  18. NcRNAs: a potential treatment for spinal cord injury.Frontiers in cellular neuroscience · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ping SunDepartment of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, S514 BST, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.
Milton H HamblinDepartment of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, Mailcode 8683, New Orleans, LA, 70112, USA.
Ke-Jie YinDepartment of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, S514 BST, 200 Lothrop Street, Pittsburgh, PA, 15213, USA. yink2@upmc.edu.
University of Pittsburgh · USTulane University · US

Funding

Long Non-Coding RNAs and Cerebral Angiogenesis in Ischemic StrokeR01NS112181 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SUN, DANDAN · 2020 to 2024
$1.8M
Role of nitro-fatty acids in BBB stabilization and post-stroke neurovascular protectionI01BX004837 · VA · VETERANS HEALTH ADMINISTRATION · PI YIN, KEJIE · 2021 to 2025
–
American Heart Association 20POST35210900BLRD VA I01 BX004837Foundation for the National Institutes of Health NS112181NINDS NIH HHS R01 NS112181U.S. Department of Veterans Affairs I01BX004837
6 · The paper itself

Abstract

The blood-brain barrier (BBB) is an essential component of the neurovascular unit that controls the exchanges of various biological substances between the blood and the brain. BBB damage is a common feature of different central nervous systems (CNS) disorders and plays a vital role in the pathogenesis of the diseases. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNA (lncRNAs), and circular RNAs (circRNAs), are important regulatory RNA molecules that are involved in almost all cellular processes in normal development and various diseases, including CNS diseases. Cumulative evidences have demonstrated ncRNA regulation of BBB functions in different CNS diseases. In this review, we have summarized the miRNAs, lncRNAs, and circRNAs that can be served as diagnostic and prognostic biomarkers for BBB injuries, and demonstrated the involvement and underlying mechanisms of ncRNAs in modulating BBB structure and function in various CNS diseases, including ischemic stroke, hemorrhagic stroke, traumatic brain injury (TBI), spinal cord injury (SCI), multiple sclerosis (MS), Alzheimer's disease (AD), vascular cognitive impairment and dementia (VCID), brain tumors, brain infections, diabetes, sepsis-associated encephalopathy (SAE), and others. We have also discussed the pharmaceutical drugs that can regulate BBB functions via ncRNAs-related signaling cascades in CNS disorders, along with the challenges, perspective, and therapeutic potential of ncRNA regulation of BBB functions in CNS diseases.

Indexed as

Blood-Brain BarrierCentral Nervous System DiseasesMicroRNAsRNA, CircularRNA, Long NoncodingBiological TransportBrainHumansMicroRNAsRNA, CircularRNA, Long NoncodingBlood–brain barrierBrain tumorCircular RNADementiaLong non-coding RNAmicroRNAMultiple sclerosisSpinal cord injuryStrokeTraumatic brain injury

Identifiers

PMID35346266
PMCPMC8959280
OpenAlexW4221132042

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.