ArticleNature medicine2022
Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers.
Article in Nature medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Pooled it
- The impact of testicular cancer and its treatment on masculinity: A systematic review.Psycho-oncology · 2022Pooled it
- Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J-SUPPORT 2001 Study).Psychiatry and clinical neurosciences · 2024Trial
- Stigma experiences among young and middle-aged testicular cancer survivors in China: A phenomenological study.Asia-Pacific journal of oncology nursing · 2026Article
- Bipolar disorder in oncology: Considerations for the psychiatrist.Journal of mood and anxiety disorders · 2026Review
- Suicide among patients with cancer: a retrospective study of medical treatment-related factors associated with suicide.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Mental Health Outcomes Among Long-Term Survivors of Childhood, Adolescent and Young Adult Cancer: A Scottish Population-Based Cohort Study.Psycho-oncology · 2026Article
- Psychological distress in cancer survivors: a population-based analysis and machine learning-based risk stratification.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- The growing and urgent need for interventions to mitigate cancer-related stigma in sub-Saharan Africa.Global mental health (Cambridge, England) · 2026Review
- Beyond Treatment, Understanding the Holistic Needs of Cancer Patients and Family Caregivers: A Qualitative Study from the Perspectives of Patients, Family Caregivers, and Health Care Providers.Cancer management and research · 2026Article
- Mapping Characteristics, Applications, and Implementation Challenges of Virtual Communities in Cancer Care: NASSS Framework-Informed Scoping Review.Journal of medical Internet research · 2025Article
- The Future of Oncology in Psychiatric Medications.Journal of clinical medicine · 2025Article
- Mental Comorbidity and Psychosocial Care in Patients with Cancer.Deutsches Arzteblatt international · 2025Article
- Incidence and predictors of immune checkpoint inhibitor treatment-related cognitive impairment in a racial and ethnic diverse population.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Article
- Psychometric assessment of the Moroccan version of the car, relax, alone, forget, friends, trouble (CRAFFT) scale among adolescent and young adults with a substance use disorder.Addiction science & clinical practice · 2025Article
- Quality of life assessment in testicular non-seminomatous germ cell tumour survivors.Journal of cancer survivorship : research and practice · 2024Article
- Global unmet psychosocial needs in cancer care: health policy.EClinicalMedicine · 2024Review
- Early, medium and long-term mental health in cancer survivors compared with cancer-free comparators: matched cohort study using linked UK electronic health records.EClinicalMedicine · 2024Article
- Anxiety and Depression in Advanced and Metastatic Lung Cancer Patients-Correlations with Performance Status and Type of Treatment.Medicina (Kaunas, Lithuania) · 2024Article
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2 authors at 2 institutions in 1 country.
Funding
Abstract
Cancer is a life-altering event causing considerable psychological distress. However, information on the total burden of psychiatric disorders across all common adult cancers and therapy exposures has remained scarce. Here, we estimated the risk of self-harm after incident psychiatric disorder diagnosis in patients with cancer and the risk of unnatural deaths after self-harm in 459,542 individuals. Depression was the most common psychiatric disorder in patients with cancer. Patients who received chemotherapy, radiotherapy and surgery had the highest cumulative burden of psychiatric disorders. Patients treated with alkylating agent chemotherapeutics had the highest burden of psychiatric disorders, whereas those treated with kinase inhibitors had the lowest burden. All mental illnesses were associated with an increased risk of subsequent self-harm, where the highest risk was observed within 12 months of the mental illness diagnosis. Patients who harmed themselves were 6.8 times more likely to die of unnatural causes of death compared with controls within 12 months of self-harm (hazard ratio (HR), 6.8; 95% confidence interval (CI), 4.3-10.7). The risk of unnatural death after 12 months was markedly lower (HR, 2.0; 95% CI, 1.5-2.7). We provide an extensive knowledge base to help inform collaborative cancer-psychiatric care initiatives by prioritizing patients who are most at risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.