Evidence map›Paper›PMID 35347312›Full record

ArticleNature structural & molecular biology2022

Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging.

Liqing Ye, Anne-Sophie Gribling-Burrer, Patrick Bohn, Anuja Kibe, Charlene Börtlein, Uddhav B Ambi, Shazeb Ahmad, Marco Olguin-Nava, Maureen Smith, Neva Caliskan and 2 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Nature structural & molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Transcription start site heterogeneity controls MDA5 sensing of unspliced HIV-1 RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  17. Role of RNA structural plasticity in modulating HIV-1 genome packaging and translation.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Liqing YeHelmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany.
Anne-Sophie Gribling-Burrer *Helmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany.
Patrick Bohn *Helmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany.
Anuja KibeHelmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany.ORCID http://orcid.org/0000-0001-8547-785X
Charlene BörtleinHelmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany.
Uddhav B AmbiHelmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany.
Shazeb AhmadHelmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany.
Marco Olguin-NavaHelmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany.
Maureen SmithP5 Systems Medicine of Infectious Disease, Robert Koch-Institute, Berlin, Germany.
Neva CaliskanHelmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany.ORCID http://orcid.org/0000-0003-0435-4757
Max von KleistP5 Systems Medicine of Infectious Disease, Robert Koch-Institute, Berlin, Germany.
Redmond P SmythHelmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany. redmond.smyth@helmholtz-hiri.de.ORCID http://orcid.org/0000-0002-1580-0671
Helmholtz Centre for Infection Research · DERobert Koch Institute · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA dimerization is the noncovalent association of two human immunodeficiency virus-1 (HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a prerequisite for binding to the viral structural protein Pr55

Indexed as

HIV-15' Untranslated RegionsDimerizationHumansNucleic Acid ConformationRNA, ViralViral Proteins5' Untranslated RegionsRNA, ViralViral Proteins

Identifiers

PMID35347312
PMCPMC9010304
OpenAlexW4225246882

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.