Layer-by-layer assembly of multilayered double hydroxides/polyoxometalate-coated magnetic nanoparticles for highly efficient phosphopeptide enrichment.

Dandan Jiang, Siqi Lv, RuiXue Qi, Xue Han, Limei Duan, Jinghai Liu

Abstract read

In one paragraph

Article in Mikrochimica acta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.8field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dandan JiangCollege of Chemistry and Materials Science, Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), Inner Mongolia Minzu University, Tongliao, 028000, People's Republic of China. jdd20091225@163.com.ORCID http://orcid.org/0000-0002-7428-2712

Siqi LvCollege of Chemistry and Materials Science, Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), Inner Mongolia Minzu University, Tongliao, 028000, People's Republic of China.

RuiXue QiCollege of Chemistry and Materials Science, Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), Inner Mongolia Minzu University, Tongliao, 028000, People's Republic of China.

Xue HanCollege of Chemistry and Materials Science, Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), Inner Mongolia Minzu University, Tongliao, 028000, People's Republic of China.

Limei DuanCollege of Chemistry and Materials Science, Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), Inner Mongolia Minzu University, Tongliao, 028000, People's Republic of China.

Jinghai LiuCollege of Chemistry and Materials Science, Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), Inner Mongolia Minzu University, Tongliao, 028000, People's Republic of China.

Inner Mongolia University for Nationalities · CN

Funding

Inner Mongolia Minzu University Doctoral Research Startup Fund Project BS513Inner Mongolia Minzu University Doctoral Research Startup Fund Project BS516National Natural Science Foundation of China 21961024National Natural Science Foundation of China 21961025National Natural Science Foundation of China 22004073Natural Science Foundation of Inner Mongolia 2020BS02010Natural Science Foundation of Inner Mongolia 2020BS02015Talent Research Support Funds from Government-Sponsored Institution of Inner Mongolia RCQD19002

6 · The paper itself

Abstract

A layer-by-layer (LbL) assembly strategy was developed to prepare multilayered double hydroxide/polyoxometalate shell-coated magnetic nanoparticles. The introduction of functional shells not only offered abundant affinity sites of metal oxide and metal ions but also increased the surface area for the contact with targets. By combining the enrichment strategies of immobilized metal ion affinity chromatography and metal oxide affinity chromatography, the nanomaterial can capture phosphopeptides via a synergistic effect. The method presented a low detection limit of 0.1 fmol in combination with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) analysis. The nanomaterial showed satisfactory selectivity (1:1:5000 M ratio of α-/β-casein/bovine serum albumin), good recovery (92.07%), high adsorption capacity (117.6 mg g

Indexed as

Magnetite NanoparticlesPhosphopeptidesAnionsCaseinsChromatography, AffinityHydroxidesOxidesPolyelectrolytesPolyoxometalatesAnionsCaseinsHydroxidesMagnetite NanoparticlesOxidesPhosphopeptidesPolyelectrolytesPolyoxometalatesImmobilized metal affinity chromatographyMALDI -TOFMetal oxide affinity chromatographyProtein phosphorylation

Identifiers

PMID35347436

DOI10.1007/s00604-022-05258-w

OpenAlexW4221066743

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.