Evidence map›Paper›PMID 35349396›Full record

ArticleAutophagy2022

Transmembrane protein ATG-9 links presynaptic autophagy with the synaptic vesicle cycle.

Sisi Yang, Daniel A Colón-Ramos

Open access · hybridAbstract readComment
In one paragraph

Article in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Sisi YangProgram in Cellular Neuroscience, Neurodegeneration and Repair, Departments of Neuroscience and of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.
Daniel A Colón-RamosProgram in Cellular Neuroscience, Neurodegeneration and Repair, Departments of Neuroscience and of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.
University of Puerto Rico System · PRYale University · US

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI ANGUS C. NAIRN, Kenneth Robert WILLIAMS · 2004 to 2026
$37.1M
Powering the Brain: the Cell Biology of NeuroenergeticsDP1NS111778 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2018 to 2022
$5.9M
MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLINGR01NS036251 · NINDS · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 1997 to 2021
$4.7M
Molecular Interplay of Endocytic ProteinsR01NS115974 · NINDS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Jihong Bai · 2020 to 2026
$4.2M
Cellular and molecular mechanisms that temporally and spatially restrict synapticR01NS076558 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2012 to 2022
$4.1M
Molecular Mechanisms in Synaptic Vesicle RecyclingR37NS036251 · NINDS · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 2010 to 2016
$2.7M
Signaling Pathways that Modulate Neuronal ActivityR01NS109476 · NINDS · UNIVERSITY OF WASHINGTON · PI Michael Ailion, Jihong Bai · 2020 to 2026
$2.5M
Molecular Mechanisms That Control the Quality of Synaptic Vesicle RecyclingR01GM127857 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BAI, JIHONG · 2018 to 2021
$2.0M
Howard Hughes Medical InstituteNIDA NIH HHS P30 DA018343NIDDK NIH HHS P30 DK045735NIGMS NIH HHS R01 GM127857NINDS NIH HHS DP1 NS111778NINDS NIH HHS R01 NS036251NINDS NIH HHS R01 NS076558NINDS NIH HHS R01 NS109476NINDS NIH HHS R01 NS115974NINDS NIH HHS R37 NS036251
6 · The paper itself

Abstract

Macroautophagy/autophagy occurs preferentially at synapses and responds to increased neuronal activity states. How synaptic autophagy is coupled to the neuronal activity state is largely unknown. Through genetic approaches we find that ATG-9, the only transmembrane protein in the core autophagy pathway, is transported from the

Indexed as

AutophagyCaenorhabditis elegansAnimalsAutophagy-Related ProteinsClathrinEndocytosisSynapsesSynaptic VesiclesAutophagy-Related ProteinsClathrinAP-3ATG-9autophagyclathrinendocytosisGolgi apparatusneuronal activity stateParkinson diseasesynaptic vesicle cyclesynaptojanin 1/UNC-26

Identifiers

PMID35349396
PMCPMC9298430
OpenAlexW4220855743

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.