SynthesisBJOG : an international journal of obstetrics and gynaecology2022
Birthweight and isolated congenital heart defects - A systematic review and meta-analysis.
Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Birthweight and isolated congenital heart defects - A systematic review and meta-analysis.BJOG : an international journal of obstetrics and gynaecology · 2022Pooled it
- The Heart of Fetal Growth Restriction: Congenital Heart Defects-An Analysis of Risk Factors and Morbidity Outcomes.Life (Basel, Switzerland) · 2026Article
- Birth Weight in Infants with a Cleft Lip and/or Palate: A Systematic Review and Meta-Analysis.The Journal of pediatrics · 2026Article
- Risk of minor congenital heart defect in infants conceived via assisted reproductive technology: cohort study from the Copenhagen Baby Heart Study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- Prognostic value of fetal growth and prenatal functional echocardiography in tetralogy of FALLOT.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Severity of Congenital Heart Defects Affects Long-Term Somatic Development.Pediatric cardiology · 2026Article
- Factors Associated With Inadequate Gestational Weight Gain: A Prospective Multicenter Cohort Study.Nursing & health sciences · 2025Article
- Adverse Obstetric Outcomes in Pregnancies With Major Fetal Congenital Heart Defects.JAMA pediatrics · 2025Article
- Fetal cardiac function in pregnancy affected by congenital heart disease: protocol for a multicentre prospective cohort study.BMC pregnancy and childbirth · 2025Article
- Exposure to Pyriproxyfen Impacts Heart Development Causing Tissue and Cellular Impairments, Heart Arrhythmia and Reduced Embryonic Growth.Cardiovascular toxicology · 2025Article
- Adverse fetal/neonatal and obstetric outcomes in pregnancies with both maternal and fetal heart disease.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Outcome and factors associated with undernutrition among children with congenital heart disease.PloS one · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBirthweight (BW) is an important prognostic factor in newborns with congenital heart defects (CHD).
objectivesTo give an overview of the literature on BW z-score in children with isolated CHD. SEARCH STRATEGY: A systematic search was performed on isolated CHD and BW in PubMed, Embase, Web of Science, COCHRANE Library and Emcare. SELECTION CRITERIA: Neonates with isolated CHD were included if a BW percentile, BW z-score or % small-or-gestational age (SGA) was reported. DATA COLLECTION AND ANALYSIS: BW z-score and percentage SGA were pooled with random-effect meta-analysis. Quality and risk of bias were assessed using the modified Newcastle Ottawa Scale. MAIN
resultsTwenty-three articles (27 893 cases) were included. BW z-scores were retrieved from 11 articles, resulting in a pooled z-score of -0.20 (95% CI -0.50 to 0.11). The overall pooled prevalence of SGA <10th percentile was 16.0% (95% CI 11.4-20.5; 14 studies). Subgroup analysis of major CHD showed similar results (BW z-score -0.23 and percentage SGA 16.2%).
conclusionsOverall BW in isolated CHD is within range of normality but impaired, with a 1.6-fold higher risk of SGA, irrespective of the type of CHD (major CHD vs all CHD combined). Our findings underline the association between CHD and BW. The use of BW z-scores provides insight into growth of all fetuses with CHD. TWEETABLE ABSTRACT: Infants with a congenital heart defect (CHD) have a lower birthweight z-score and a higher incidence of small-for-gestational age (<10th percentile). This was encountered both in the major CHD-group as well as in all-CHD combined group analysis. Future research on the association between birthweight and CHD should include all types of CHDs (including mild cardiac defects) and placental-related disease, such as pre-eclampsia. We advocate the use of international standardised fetal growth and birthweight charts in CHD research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.