Evidence map›Paper›PMID 35354010›Full record

ArticleThe western journal of emergency medicine2021

Severe Vitamin K-dependent Coagulopathy from Rodenticide-contaminated Synthetic Cannabinoids: Emergency Department Presentations.

Erik Wright, John W Hafner, Gregory Podolej, Douglas L Feinstein, Richard van Breemen, Israel Rubinstein, Steven Aks, Michael Wahl

Open access · goldAbstract read
In one paragraph

Article in The western journal of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Vitamin K Deficiency: Diagnosis and Management.Annals of laboratory medicine · 2025
    Review
  2. Article
  3. Non-adherence with long-term oral vitamin KToxicology communications · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Erik WrightUniversity of Illinois College of Medicine Peoria, OSF Saint Francis Medical Center, Department of Emergency Medicine, Peoria, Illinois.
John W HafnerUniversity of Illinois College of Medicine Peoria, Department of Emergency Medicine, Peoria, Illinois.
Gregory PodolejUniversity of Illinois College of Medicine Peoria, Department of Emergency Medicine, Peoria, Illinois.
Douglas L FeinsteinUniversity of Illinois Chicago, Jesse Brown VA Medical Center, Department of Anesthesiology, Chicago, Illinois.
Richard van BreemenOregon State University, Linus Pauling Institute, Department of Pharmaceutical Sciences, Corvallis, Oregon.
Israel RubinsteinUniversity of Illinois Chicago, Jesse Brown VA Medical Center, Division of Pulmonary, Critical Care, Sleep, and Allergy Medicine, Chicago, Illinois.
Steven AksRush University, Department of Emergency Medicine, Chicago, Illinois.
Michael WahlJohn H. Stroger Hospital of Cook County, Department of Emergency Medicine, Chicago, Illinois.
Jesse Brown VA Medical Center · USIllinois College · USJohn H. Stroger, Jr. Hospital of Cook County · USOregon State University · USOSF Saint Francis Medical Center · USRush University · USUniversity of Illinois Chicago · US

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Intralipid: A novel frontline countermeasure for brodifacoum poisoningU01NS083457 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FEINSTEIN, DOUGLAS L. · 2013 to 2018
$3.6M
Optimization of Bile Sequestrants to Treat Superwarfarin PoisoningU01NS127746 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Douglas L. Feinstein · 2022 to 2026
$3.3M
BLRD VA IK6 BX004852NIEHS NIH HHS P30 ES027792NINDS NIH HHS U01 NS083457NINDS NIH HHS U01 NS127746
6 · The paper itself

Abstract

introductionSynthetic cannabinoids are a rapidly expanding subset of designer drugs widely available in the United States since 2008. In Illinois during the spring of 2018, over 160 documented cases of bleeding and prolonged coagulopathy occurred secondary to contaminated synthetic cannabinoids.

methodsWe conducted a retrospective cohort study consisting of 38 patients to describe the initial emergency department (ED) presentation, diagnosis, and treatment.

resultsThrough serum testing we found that three long-acting anticoagulant rodenticides (LAAR) were detected in patients who had inhaled these tainted products: brodifacoum, difenacoum, and bromodialone. DISCUSSION: This study encompasses the largest ED presentation of LAAR poisoning via the inhalational route known to date.

conclusionThe emergency physician should be aware of the potential for tainted coingestants as the cause of undifferentiated coagulopathy.

Indexed as

CannabinoidsRodenticidesEmergency Service, HospitalHumansRetrospective StudiesUnited StatesVitamin KCannabinoidsRodenticidesVitamin K

Identifiers

PMID35354010
PMCPMC8328164
OpenAlexW3186534699

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.