ArticleNature2022
Anatomic position determines oncogenic specificity in melanoma.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 93 citations in OpenAlex.
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- Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features.bioRxiv : the preprint server for biology · 2026Article
- A Targetable Developmental Program Coregulates Angiogenesis and Immune Evasion in Melanoma.Cancer discovery · 2026Article
- Somatic mutations distinguish melanocyte subpopulations in human skin.Nature cell biology · 2026Article
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- Poor efficacy of anti PD-1 antibody based immunotherapy in patients with acral melanoma: results from the Spanish Melanoma Group (GEM) registry.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Modeling rare melanoma subtypes: mechanisms, microenvironments and translational opportunities.Frontiers in oncology · 2026Review
- Mechanisms of Immune Checkpoint Inhibitor Resistance in Hepatocellular Carcinoma and Strategies for Reversal.Cancers · 2025Review
- SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence.Nature cancer · 2025Article
- USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A single-cell spatial transcriptomic census of human skin anatomy.bioRxiv : the preprint server for biology · 2025Article
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- Modelling Acral Melanoma in Admixed Brazilians Uncovers Genomic Drivers and Targetable Pathways.medRxiv : the preprint server for health sciences · 2025Article
- Ancestry and somatic profile predict acral melanoma origin and prognosis.medRxiv : the preprint server for health sciences · 2025Article
- Specific oncogene activation of the cell of origin in mucosal melanoma.Nature communications · 2025Article
- Identification of two molecularly and prognostically distinct subtypes in acral melanoma using network prediction method.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
40 authors at 6 institutions in 3 countries.
Joshua M WeissWeill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
Miranda V HunterDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6971-1738
Nelly M CruzDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-9040-6957
Arianna BaggioliniDevelopmental Biology, The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2476-561X
Mohita TagoreDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2586-1427
Yilun MaWeill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
Sandra MisaleMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michelangelo MarascoMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Theresa Simon-VermotDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nathaniel R CampbellWeill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.ORCID http://orcid.org/0000-0002-0355-0708
Felicity NewellQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-0469-2705
James S WilmottMelanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.
Peter A JohanssonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
John F ThompsonMelanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-2816-2496
Georgina V LongMelanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-8894-3545
John V PearsonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Graham J MannMelanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.
Richard A ScolyerMelanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.
Nicola WaddellQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-3950-2476
Emily D MontalDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ting-Hsiang HuangDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Philip JonssonHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1537-0624
Mark T A DonoghueHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Christopher C HarrisHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Barry S TaylorHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tianhao XuComputational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ronan ChalignéComputational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4332-3291
Pavel V ShliahaDepartment of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Odense, Denmark.
Ronald HendricksonMicrochemistry and Proteomics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Achim A JungbluthDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cecilia LezcanoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Richard KocheCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6820-5083
Lorenz StuderDevelopmental Biology, The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0741-7987
Charlotte E AriyanDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
David B SolitHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6614-802X
Jedd D WolchokHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-6718-2222
Taha MerghoubWeill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-1518-5111
Neal RosenMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8307-654X
Nicholas K HaywardQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Richard M WhiteDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. whiter@mskcc.org.ORCID http://orcid.org/0000-0001-9099-9169
Memorial Sloan Kettering Cancer Center · USQIMR Berghofer Medical Research Institute · AUThe University of Sydney · AUAustralian National University · AUCornell University · USThe University of Queensland · AU
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MTRAINING PROGRAM IN MOLECULAR AND CELLULAR BIOLOGYT32GM008539 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BROWN, ANTHONY M.C. · 1995 to 2020
$5.0MDissecting the complexity of metastasis with mathematical models and quantitative experiments with in zebrafishR01CA229215 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK, XAVIER, JOAO · 2018 to 2022
$3.1MEvolutionary dynamics of melanoma metastasisDP2CA186572 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK · 2013 to 2013
$2.7MLipid programs in melanocyte transformationR01CA238317 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI OVERHOLTZER, MICHAEL H., WHITE, RICHARD MARK · 2020 to 2025
$2.0MLTQ-ORBITRAP VELOS Tandem Mass SpectrometerS10OD010598 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI HENDRICKSON, RONALD CHARLES · 2012 to 2012
$460kInvestigating cancer metabolism and its potential for therapeutic interventionK00CA223016 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MONTAL, EMILY DINA · 2019 to 2022
$391kDissecting the Ecology of Metastasis in a Zebrafish Model: Trade-Offs of Size and Diversity in Circulating Tumor Cell ClustersF30CA220954 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CAMPBELL, NATHANIEL R · 2018 to 2021
$194kInvestigating the Role of Adipocyte Lipolysis in Melanoma ProgressionF30CA236442 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI WEISS, JOSHUA M. · 2019 to 2022
$186kMedical Research CouncilNCI NIH HHS DP2 CA186572NCI NIH HHS F30 CA220954NCI NIH HHS F30 CA236442NCI NIH HHS K00 CA223016NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA229215NCI NIH HHS R01 CA238317NIGMS NIH HHS T32 GM007739NIGMS NIH HHS T32 GM008539NIH HHS S10 OD010598
Abstract
Oncogenic alterations to DNA are not transforming in all cellular contexts
Indexed as
MelanomaSkin NeoplasmsAnimalsAnimals, Genetically ModifiedCarcinogenesisCutaneous Malignant MelanomaFootHandHumansNailsOncogenesTranscription, GeneticZebrafish
Identifiers
What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.