Evidence map›Paper›PMID 35359443›Full record

ReviewFrontiers in cell and developmental biology2022

Ras and Rab Interactor 3: From Cellular Mechanisms to Human Diseases.

Ruinan Shen, Caitlin J Murphy, Xiaowen Xu, Mingzheng Hu, Jianqing Ding, Chengbiao Wu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Science advances · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Genome assemblies forFrontiers in genetics · 2024
    Article
  11. Review
  12. Article
  13. Update on the pathogenesis and genetics of Paget's disease of bone.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ruinan ShenInstitute of Neurology, Ruijing Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Caitlin J MurphyDepartment of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA, United States.
Xiaowen XuDepartment of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA, United States.
Mingzheng HuDepartment of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA, United States.
Jianqing DingInstitute of Neurology, Ruijing Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Chengbiao WuDepartment of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA, United States.
University of California, San Diego · USRuijin Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ras and Rab interactor 3 (RIN3) functions as a Guanine nucleotide Exchange Factor (GEF) for some members of the Rab family of small GTPase. By promoting the activation of Rab5, RIN3 plays an important role in regulating endocytosis and endocytic trafficking. In addition, RIN3 activates Ras, another small GTPase, that controls multiple signaling pathways to regulate cellular function. Increasing evidence suggests that dysregulation of RIN3 activity may contribute to the pathogenesis of several disease conditions ranging from Paget's Disease of the Bone (PDB), Alzheimer's Disease (AD), Chronic Obstructive Pulmonary Disease (COPD) and to obesity. Recent genome-wide association studies (GWAS) identified variants in the

Indexed as

Alzheimer’s diseaseendocytosisRab5RIN3trafficking

Identifiers

PMID35359443
PMCPMC8963869
OpenAlexW4221035782

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.