ArticleFrontiers in aging neuroscience2022
The Effects of Electroencephalogram Feature-Based Transcranial Alternating Current Stimulation on Working Memory and Electrophysiology.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Is transcranial alternating current stimulation effective for improving working memory? A three-level meta-analysis.Psychonomic bulletin & review · 2025Pooled it
- Randomized, double-blind, sham-controlled pilot trial of theta-band transcranial alternating current stimulation during cognitive training in mild Alzheimer's disease.Translational psychiatry · 2026Trial
- Effect of theta-transcranial alternating current stimulation on working memory performance among healthy adults: A systematic review and meta-analysis.World journal of psychiatry · 2025Article
- Phase-lagged tACS between executive and default mode networks modulates working memory.Scientific reports · 2025Article
- Exploring the Impact of Declarative Learning on the Consolidation of Acquired Motor Skills Under Valence Feedback.Human brain mapping · 2025Article
- Cross-frequency neuromodulation: leveraging theta-gamma coupling for cognitive rehabilitation in MCI patients.Frontiers in aging neuroscience · 2025Article
- Improving working memory by electrical stimulation and cross-frequency coupling.Molecular brain · 2024Article
- Causal functional maps of brain rhythms in working memory.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Research progress on the intervention of cognitive function using transcranial alternating current stimulation technology.Frontiers in psychology · 2024Article
- No effects of the theta-frequency transcranial electrical stimulation for recall, attention control, and relation integration in working memory.Frontiers in human neuroscience · 2024Article
- Brain State-Dependent Non-Invasive Neurostimulation with EEG Feedback: Achievements and Prospects (Review).Sovremennye tekhnologii v meditsine · 2023Review
- Transcranial Electrical Stimulation Offers the Possibility of Improving Teamwork Among Military Pilots: A Review.Frontiers in neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial alternating current stimulation (tACS) can influence cognitive functions by modulating brain oscillations. However, results regarding the effectiveness of tACS in regulating cognitive performance have been inconsistent. In the present study, we aimed to find electroencephalogram (EEG) characteristics associated with the improvements in working memory performance, to select tACS stimulus targets and frequency based on this feature, and to explore effects of selected stimulus on verbal working memory. To achieve this goal, we first investigated the EEG characteristics associated with improvements in working memory performance with the aid of EEG analyses and machine learning techniques. These analyses suggested that 8 Hz activity in the prefrontal region was related to accuracy in the verbal working memory task. The tACS stimulus target and pattern were then selected based on the EEG feature. Finally, the selected tACS frequency (8 Hz tACS in the prefrontal region) was applied to modulate working memory. Such modulation resulted significantly greater improvements, compared with 40 Hz and sham modulations (especially for participants with weak verbal working memory). In conclusion, using EEG features related to positive behavioral changes to select brain regions and stimulation patterns for tACS is an effective intervention for improving working memory. Our results contribute to the groundwork for future tACS closed-loop interventions for cognitive deterioration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.