ArticlePNAS nexus2022
Short-term bioelectric stimulation of collective cell migration in tissues reprograms long-term supracellular dynamics.
Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Cell jamming transition is regulated by mitochondrial pyruvate transport and endocytosis.bioRxiv : the preprint server for biology · 2026Article
- Galvanotactic directionality of cell groups depends on group size.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Electrotaxis disrupts patterns of cell-cell interactions of human corneal epithelial cells in vitro.Biophysical journal · 2025Article
- Stretch-induced endogenous electric fields drive directed collective cell migration in vivo.Nature materials · 2025Article
- Article
- Gut epithelial electrical cues drive differential localization of enterobacteria.Nature microbiology · 2024Article
- A quadriphasic mechanical model of the human dermis.Biomechanics and modeling in mechanobiology · 2024Article
- Optimal Control of Collective Electrotaxis in Epithelial Monolayers.Bulletin of mathematical biology · 2024Article
- Bioelectric stimulation controls tissue shape and size.Nature communications · 2024Article
- Collective intelligence: A unifying concept for integrating biology across scales and substrates.Communications biology · 2024Review
- Spatial heterogeneity in collective electrotaxis: continuum modelling and applications to optimal control.bioRxiv : the preprint server for biology · 2024Article
- E-cadherin biomaterials reprogram collective cell migration and cell cycling by forcing homeostatic conditions.Cell reports · 2024Article
- Article
- Electrotaxis of alveolar epithelial cells in direct-current electric fields.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2023Article
- Bioelectronic microfluidic wound healing: a platform for investigating direct current stimulation of injured cell collectives.Lab on a chip · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The ability to program collective cell migration can allow us to control critical multicellular processes in development, regenerative medicine, and invasive disease. However, while various technologies exist to make individual cells migrate, translating these tools to control myriad, collectively interacting cells within a single tissue poses many challenges. For instance, do cells within the same tissue interpret a global migration 'command' differently based on where they are in the tissue? Similarly, since no stimulus is permanent, what are the long-term effects of transient commands on collective cell dynamics? We investigate these questions by bioelectrically programming large epithelial tissues to globally migrate 'rightward' via electrotaxis. Tissues clearly developed distinct rear, middle, side, and front responses to a single global migration stimulus. Furthermore, at no point poststimulation did tissues return to their prestimulation behavior, instead equilibrating to a 3rd, new migratory state. These unique dynamics suggested that programmed migration resets tissue mechanical state, which was confirmed by transient chemical disruption of cell-cell junctions, analysis of strain wave propagation patterns, and quantification of cellular crowd dynamics. Overall, this work demonstrates how externally driving the collective migration of a tissue can reprogram baseline cell-cell interactions and collective dynamics, even well beyond the end of the global migratory cue, and emphasizes the importance of considering the supracellular context of tissues and other collectives when attempting to program crowd behaviors.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.