Evidence map›Paper›PMID 35361621›Full record

Trial reportBMJ open diabetes research & care2022

Incidence of atrial fibrillation in elderly patients with type 2 diabetes mellitus.

Chisa Matsumoto, Hisao Ogawa, Yoshihiko Saito, Sadanori Okada, Hirofumi Soejima, Mio Sakuma, Izuru Masuda, Masafumi Nakayama, Naofumi Doi, Hideaki Jinnouchi and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open diabetes research & care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00110448 (Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00110448 phase4completednot on this map

Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial

TypeinterventionalSponsorKumamoto UniversityRan2002 to 2008Enrolled2,539ConditionsCoronary Disease, Arteriosclerosis, Diabetes Mellitus, Type 2ArmsAspirin, No aspirin
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Chisa MatsumotoDepartment of Cardiology, Center for Health Surveillance and Preventive Medicine, Tokyo Medical University Hospital, Shinjuku, Japan.
Hisao OgawaKumamoto University, Kumamoto, Japan.
Yoshihiko SaitoDepartment of Cardiovascular Medicine, Nara Medical University, Kashihara, Nara, Japan.
Sadanori OkadaDepartment of Diabetes and Endocrinology, Nara Medical University, Kashihara, Nara, Japan.
Hirofumi SoejimaDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-7520-2008
Mio SakumaDepartment of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan.
Izuru MasudaTakeda Hospital Medical Examination Center, Kyoto, Japan.
Masafumi NakayamaNakayama Cardiovascular Clinic, Kumamoto, Japan.
Naofumi DoiDepartment of Cardiovascular Medicine, Nara Prefecture Seiwa Medical Center, Nara, Japan.
Hideaki JinnouchiDepartment of Internal Medicine, Jinnouchi Hospital Diabetes Care Center, Kumamoto, Japan.
Masako WakiFood Safety Commission of Japan, Tokyo, Japan.
Takeshi MorimotoDepartment of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan morimoto@kuhp.kyoto-u.ac.jp.ORCID 0000-0002-6844-739X
Nara Medical University · JPHyogo Medical University · JPKumamoto Health Science University · JPKumamoto University · JPMinamiaoyama Eye Clinic · JPTakeda (Japan) · JPTokyo Medical University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe incidence of atrial fibrillation (AF), a significant risk factor for cardiovascular disease (CVD), is increasing worldwide. Type 2 diabetes mellitus (T2D) and advanced age are recognized as major risk factors for AF, but herein, we evaluated the incidence of AF in elderly patients with T2D and compared the prognosis between these patients with/without AF. RESEARCH DESIGN AND

methodsThe Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD2) study is a follow-up cohort study of the JPAD trial, a randomized controlled clinical trial initiated in 2002 in 2535 Japanese patients with T2D, to examine whether low-dose aspirin prevents CVD. After completion of that trial, we followed up the patients until 2019 and evaluated the incidence of AF. We also compared the incidence of cerebral cardiovascular events in elderly patients with T2D with/without AF.

resultsDuring the median follow-up period of 10.9 years, 132 patients developed AF (incidence rate: 5.14/1000 person-years). The adjusted HRs for cerebral cardiovascular events, stroke, coronary artery disease, heart failure, and all-cause death in elderly patients with T2D with versus without AF were 1.65 (95% CI 1.03 to 2.66), 1.54 (95% CI 0.81 to 2.93), 1.96 (95% CI 1.03 to 3.73), 5.17 (95% CI 2.46 to 10.89), and 1.82 (95% CI 1.24 to 2.67), respectively.

conclusionsAnnually, 1 in 200 elderly Japanese patients with T2D are estimated to develop AF. Because elderly patients with T2D with AF are at an elevated risk for CVD, careful follow-up of this patient subgroup is necessary. TRIAL REGISTRATION NUMBER: NCT00110448.

Indexed as

Atrial FibrillationDiabetes Mellitus, Type 2AgedAspirinFollow-Up StudiesHumansIncidenceAspirinatrial fibrillation

Identifiers

PMID35361621
PMCPMC8971791
OpenAlexW4220784088

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.