Evidence map›Paper›PMID 35367412›Full record

ArticleThe Journal of biological chemistry2022

Cathepsin D interacts with adenosine A

Adrienn Skopál, Tamás Kéki, Péter Á Tóth, Balázs Csóka, Balázs Koscsó, Zoltán H Németh, Luca Antonioli, Andreas Ivessa, Francisco Ciruela, László Virág and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Adenosine-mediated immune responses in inflammatory bowel disease.Frontiers in cell and developmental biology · 2024
    Review
  8. Adenosine ACurrent issues in molecular biology · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 4 countries.

Adrienn SkopálDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, Hungary.
Tamás KékiDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, Hungary.
Péter Á TóthDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Balázs CsókaDepartment of Anesthesiology, Columbia University, New York, New York, USA.
Balázs KoscsóDepartment of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Zoltán H NémethDepartment of Anesthesiology, Columbia University, New York, New York, USA; Department of Surgery, Morristown Medical Center, Morristown, New Jersey, USA.
Luca AntonioliDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Andreas IvessaDepartment of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Francisco CiruelaPharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain; Neuropharmacology and Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, L'Hospitalet de Llobregat, Barcelona, Spain.
László VirágDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; MTA-DE Cell Biology and Signaling Research Group, University of Debrecen, Debrecen, Hungary.
György HaskóDepartment of Anesthesiology, Columbia University, New York, New York, USA. Electronic address: gh2503@cumc.columbia.edu.
Endre KókaiDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address: ekokai@med.unideb.hu.
University of Debrecen · HUBellvitge University Hospital · ESColumbia University · USColumbia University Irving Medical Center · USMorristown Medical Center · USRutgers, The State University of New Jersey · USUniversity of Massachusetts Chan Medical School · USUniversity of Pisa · IT

Funding

Purinergic signaling in trauma and sepsisR01GM066189 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI HASKO, GEORGE · 2002 to 2020
$4.7M
Neutrophil A2A receptors in sepsisR01HL158519 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HASKO, GEORGE · 2021 to 2024
$2.1M
Purinergic signaling in granuloma-forming Th2 immunityR01DK113790 · NIDDK · RBHS-NEW JERSEY MEDICAL SCHOOL · PI GAUSE, WILLIAM CLARK, HASKO, GEORGE · 2017 to 2020
$1.9M
NHLBI NIH HHS R01 HL158519NIDDK NIH HHS R01 DK113790NIGMS NIH HHS R01 GM066189
6 · The paper itself

Abstract

Adenosine A

Indexed as

AdenosineReceptor, Adenosine A2AAnimalsCarrier ProteinsCathepsin DMacrophagesMiceSignal TransductionAdenosineCarrier ProteinsCathepsin DCtsd protein, mouseReceptor, Adenosine A2Aadenosine receptorcathepsin Dinflammationmacrophageprotein interaction

Identifiers

PMID35367412
PMCPMC9065627
OpenAlexW4220845199

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.