Evidence map›Paper›PMID 35369106›Full record

ArticleFrontiers in nutrition2022

Prevention of High-Fat Diet-Induced Hypercholesterolemia by

Mengyao Lu, Jin Sun, Yuning Zhao, Haowen Zhang, Xinyue Li, Jingbo Zhou, Hongyang Dang, Jidong Zhang, Wenjing Huang, Ce Qi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Microorganisms · 2026
    Article
  5. Impact of Dietary Interventions withFoods (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Mengyao LuInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Jin SunInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Yuning ZhaoInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Haowen ZhangInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Xinyue LiInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Jingbo ZhouInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Hongyang DangInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Jidong ZhangDepartment of Cardiology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
Wenjing HuangDepartment of Paediatrics, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
Ce QiInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Duo LiInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Methods: C57BL/6N mice were fed a low-fat diet or a high-fat diet and gavage with Fn041 and Results: Both Fn041 and LGG prevented the occurrence of hypercholesterolemia, liver and testicular fat accumulation. In addition, a high-fat diet causes intestinal dysbiosis and mucosal barrier damage, which is associated with hypercholesterolemia. Fn041 prevented the high-fat diet-induced reduction in alpha diversity of intestinal microbiota and intestinal mucosal barrier damage. Fn041 treatment significantly increased fecal total cholesterol and total bile acids. Conclusions: Fn041 prevented hypercholesterolemia by enhancing cholesterol excretion and mucosal barrier function.

Indexed as

bile acidcholesterolgut microbiotahigh-fat dietLactobacillus reuteri

Identifiers

PMID35369106
PMCPMC8967143
OpenAlexW4220926611

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.