ReviewFrontiers in cardiovascular medicine2022
Carotid Artery Stiffness: Imaging Techniques and Impact on Cerebrovascular Disease.
Review in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Noninvasive Assessment of Arterial Compliance and Lumen Pressure in Human Carotid Arteries Using Physics-Informed Neural Networks and Ultrasound Imaging: A Clinical Feasibility Study.Research square · 2026Article
- Role of characteristic impedance in carotid stiffness and cognitive dysfunction: interaction with proximal aortic stiffness.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Recent advances in vascular ultrasound imaging technology and their clinical implications.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Review
- Assessment of Spatially-Varying Arterial Wall Stiffness and Pressure Using a Physics-Informed Neural Network and Pulse Wave Imaging: An in Silico and Experimental Phantom Study of Stenotic Vessels.Ultrasound in medicine & biology · 2026Article
- Carotid and regional arterial stiffness and dementia-related imaging biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank.IBRO neuroscience reports · 2025Article
- Lower diastolic velocity in the internal carotid artery mediates lower cerebral blood flow with age.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Longitudinal associations of carotid artery stiffness with progression of cerebrovascular disease, incident dementia and cognitive decline in older adults.The journal of prevention of Alzheimer's disease · 2025Article
- Estimation of In Vivo Human Carotid Artery Elasticity Using Arterial Dispersion Ultrasound Vibrometry.Ultrasound in medicine & biology · 2025Article
- Article
- Correlation between Neuroimaging Scores and Carotid Artery Ultrasound Features in Cerebral Small Vessel Disease Patients.Cerebrovascular diseases extra · 2025Article
- Brain compliance: a new assessment for clinical practice?Frontiers in cardiovascular medicine · 2025Review
- Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age.Journal of the American Heart Association · 2024Article
- Comparison of Parameters for Assessment of Carotid Stiffness and Their Association with Carotid Atherosclerosis in Rural Australian Adults: A Pilot Study.Journal of clinical medicine · 2023Article
- Integrating Ultrasound-Derived Carotid Artery Stiffness in the Assessment of Cardiovascular Risk.Cardiology & vascular research (Wilmington, Del.) · 2023Article
- Effects of Carotid Artery Stiffness on Cerebral Small-Vessel Disease and Cognition.Journal of the American Heart Association · 2022Article
- Association of arterial structure and function with incident cardiovascular diseases and cognitive decline.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Arterial stiffness is an important measure of vascular aging and atherosclerosis. Though it is measured in many well-known epidemiologic cohort studies, arterial stiffness is often overlooked in routine clinical practice for a number of reasons including difficulties in measurement, variations in definition, and uncertainties surrounding treatment. Central arterial stiffness, a surrogate for aortic stiffness, is the most commonly measured marker of arterial stiffness. In addition to central stiffness, there are also a number of ultrasound based techniques to measure local vascular stiffness, including carotid stiffness. There is evidence that both local carotid stiffness and central arterial stiffness measures are associated with multiple cerebrovascular processes, including stroke and cognitive dysfunction. Mechanistic explanations supporting this association include increased flow load experienced by the cerebral microvasculature leading to cerebral parenchymal damage. In this article, we review definitions of carotid artery stiffness measures and pathophysiologic mechanisms underpinning its association with plaque development and downstream cerebral pathology. We will review the evidence surrounding the association of carotid stiffness measures with downstream manifestations including stroke, cerebral small vessel disease detected on brain MR such as white matter hyperintensities and covert brain infarctions, brain atrophy, and cognitive dysfunction. With consistent definitions, measurement methods, and further scientific support, carotid stiffness may have potential as an imaging-based risk factor for stroke and cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.