ArticleFrontiers in medicine2022
Air Trapping and the Risk of COPD Exacerbation: Analysis From Prospective KOCOSS Cohort.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Breathing insights: Biomarkers as tools for chronic obstructive pulmonary disease assessment - A systematic review.Indian journal of pharmacology · 2026Pooled it
- Comparative Real-World Effectiveness of Fixed-Dose Triple Therapy Regimens in COPD: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Integrating network annotation from multiple correlated traits to improve polygenic risk scores based on GWAS summary statistics.Research square · 2026Article
- Expiratory Muscle Strength, Peak Oxygen Consumption and Hyperinflation Predicts Severe Exacerbation in Chronic Obstructive Pulmonary Disease Patients.Thoracic research and practice · 2026Article
- Risk Factors for Progression to Frequent Exacerbators in Stable Patients with Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2026Article
- Effects of Vaccination on Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Cohort Study.Tuberculosis and respiratory diseases · 2025Article
- Kernel Conversion Improves the Correlation between the Extent of Emphysema and Clinical Parameters in Chronic Obstructive Pulmonary Disease: A Multicenter Cohort Study.Tuberculosis and respiratory diseases · 2025Article
- Risk of acute exacerbation of chronic obstructive pulmonary disease after COVID-19 recovery: a nationwide population-based cohort study.Respiratory research · 2025Article
- Air trapping in patients with idiopathic pulmonary fibrosis: a retrospective case-control study.Scientific reports · 2025Article
- Beyond the Spirometry: New Diagnostic Modalities in Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2025Article
- Age-related lung structure changes by quantitative assessment: a cross-sectional study in a Chinese male cohort.Frontiers in aging · 2025Article
- Correlation between handgrip strength and air trapping in patients with stable chronic obstructive pulmonary disease.Journal of thoracic disease · 2024Article
- Factors Associated with the Discrepancy between Exercise Capacity and Airflow Limitation in Patients with Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2024Article
- Rheumatoid arthritis-associated airway disease: longitudinal pulmonary function behavior.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Article
- Simulated obstructive respiratory disease dataset over increasing positive end-expiratory pressure.Data in brief · 2024Article
- Assessment of lung hyperinflation in occupational chronic obstructive pulmonary disease: a multicentric cross-sectional study.BMJ open respiratory research · 2023Article
- FVC, but not FEVScientific reports · 2022Article
- Phenotyping COPD Patients with Emphysema Distribution Using Quantitative CT Measurement; More Severe Airway Involvement in Lower Dominant Emphysema.International journal of chronic obstructive pulmonary disease · 2022Article
- Understanding exacerbation risk in BLVR: A logistic regression approach to complication prediction.Chronic respiratory diseaseArticle
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Authors and funding
10 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Air trapping is a predictive index for a decline in lung function and mortality in patients with chronic obstructive pulmonary disease (COPD). However, the role of air trapping in COPD exacerbation has rarely been studied. Therefore, this study aimed to investigate the impact of air trapping as a continuous parameter on COPD exacerbation. Materials and Methods: To evaluate air trapping, we identified the ratio of residual volume (RV) to total lung capacity (TLC) of patients with COPD from the Korean COPD Subgroup Study (KOCOSS) cohort, which is a multicenter-based, prospective, consecutive cohort in Korea. The primary outcome was a development of COPD exacerbation during 3 years of follow-up. Results: Of 2,181 participants, 902 patients measured the RV/TLC ratio in the baseline enrollment, and 410 were evaluated for assessing the development of COPD exacerbation. Of 410 patients, the rate of moderate to severe exacerbation and severe exacerbation was 70.7% and 25.9%. A 10% increase of RV/TLC ratio increased the risk of the moderate to severe exacerbation by 35% and severe exacerbation by 36%. In subgroup analysis, an interaction effect between triple inhaled therapy and the RV/TLC ratio for severe exacerbation nullified the association between the RV/TLC ratio and severe exacerbation ( Conclusions: In this prospective cohort study, we found that air trapping (representing RV/TLC ratio as a continuous parameter) showed an association with an increased risk of COPD exacerbation, particularly in patients who have not undergone triple inhaler therapy.
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