ReviewKidney3602020
Bioenergetic Evolution Explains Prevalence of Low Nephron Number at Birth: Risk Factor for CKD.
Review in Kidney360, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- The Impact of Low-Protein Diet on the Molecular and Cellular Development of the Fetal Kidney.Journal of the American Society of Nephrology : JASN · 2026Article
- Kidney care at NICU discharge and follow-up recommendations for preterm infants<34 weeks.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Maternal nutrition can rapidly rescue a nephron deficit in low birthweight offspring.npj metabolic health and disease · 2025Article
- Kidney complications in children with bronchopulmonary dysplasia.Pediatric research · 2025Article
- Evolutionary medicine of emunctory functions of the kidney: an empirical review.Evolution, medicine, and public health · 2025Review
- A comprehensive review on indigenous therapeutic approaches in kidney care using Ayush medicine.Frontiers in pharmacology · 2025Review
- Kidney Health Monitoring in Neonatal Intensive Care Unit Graduates: A Modified Delphi Consensus Statement.JAMA network open · 2024Article
- Sirtuins in kidney health and disease.Nature reviews. Nephrology · 2024Review
- Advances in pediatric acute kidney injury pathobiology: a report from the 26th Acute Disease Quality Initiative (ADQI) conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- The impact of intrauterine growth restriction and prematurity on nephron endowment.Nature reviews. Nephrology · 2023Review
- CAKUT: A Pediatric and Evolutionary Perspective on the Leading Cause of CKD in Childhood.Pediatric reports · 2023Review
- Impact of early life development on later onset chronic kidney disease and hypertension and the role of evolutionary trade-offs.Experimental physiology · 2022Review
- Critical windows of perinatal particulate matter (PMEnvironmental research · 2022Article
- Prenatal blood lead levels and reduced preadolescent glomerular filtration rate: Modification by body mass index.Environment international · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is greater than tenfold variation in nephron number of the human kidney at birth. Although low nephron number is a recognized risk factor for CKD, its determinants are poorly understood. Evolutionary medicine represents a new discipline that seeks evolutionary explanations for disease, broadening perspectives on research and public health initiatives. Evolution of the kidney, an organ rich in mitochondria, has been driven by natural selection for reproductive fitness constrained by energy availability. Over the past 2 million years, rapid growth of an energy-demanding brain in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.