Evidence map›Paper›PMID 35373216›Full record

ArticlePLOS digital health2022

An explainable artificial intelligence approach for predicting cardiovascular outcomes using electronic health records.

Sergiusz Wesołowski, Gordon Lemmon, Edgar J Hernandez, Alex Henrie, Thomas A Miller, Derek Weyhrauch, Michael D Puchalski, Bruce E Bray, Rashmee U Shah, Vikrant G Deshmukh and 5 more

Open access · goldAbstract read
In one paragraph

Article in PLOS digital health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  3. Role of artificial intelligence in congenital heart disease.World journal of clinical pediatrics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Sergiusz WesołowskiDepartment of Human Genetics and Utah Center for Genetic Discovery, University of Utah, Salt Lake City, UT, United States of America.ORCID 0000-0002-9560-723X
Gordon LemmonDepartment of Human Genetics and Utah Center for Genetic Discovery, University of Utah, Salt Lake City, UT, United States of America.ORCID 0000-0002-8381-205X
Edgar J HernandezDepartment of Human Genetics and Utah Center for Genetic Discovery, University of Utah, Salt Lake City, UT, United States of America.ORCID 0000-0003-1455-8251
Alex HenrieDepartment of Human Genetics and Utah Center for Genetic Discovery, University of Utah, Salt Lake City, UT, United States of America.
Thomas A MillerDivision of Pediatric Cardiology, University of Utah School of Medicine, Salt Lake City, UT, United States of America.ORCID 0000-0001-5498-7021
Derek WeyhrauchDivision of Pediatric Cardiology, University of Utah School of Medicine, Salt Lake City, UT, United States of America.ORCID 0000-0002-9059-4062
Michael D PuchalskiDivision of Pediatric Cardiology, University of Utah School of Medicine, Salt Lake City, UT, United States of America.
Bruce E BrayDivision of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States of America.ORCID 0000-0003-3963-2964
Rashmee U ShahDivision of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States of America.ORCID 0000-0002-7823-8540
Vikrant G DeshmukhUniversity of Utah Health Care CMIO Office, Salt Lake City, UT, United States of America.
Rebecca DelaneyDepartment of Population Health Sciences, University of Utah, Salt Lake City, UT, United States of America.
H Joseph YostMolecular Medicine Program, University of Utah, Salt Lake City, UT, United States of America.ORCID 0000-0003-2961-5669
Karen EilbeckDepartment of Population Health Sciences, University of Utah, Salt Lake City, UT, United States of America.ORCID 0000-0002-0831-6427
Martin Tristani-FirouziDivision of Pediatric Cardiology, University of Utah School of Medicine, Salt Lake City, UT, United States of America.ORCID 0000-0001-5916-442X
Mark YandellDepartment of Human Genetics and Utah Center for Genetic Discovery, University of Utah, Salt Lake City, UT, United States of America.
University of Utah · USUniversity of Utah Health Care · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
University of Utah Interdisciplinary Training Program in Computational Approaches to Diabetes and Metabolism ResearchT32DK110966 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Karen Louise Eilbeck, Marcus Guy Pezzolesi · 2016 to 2026
$2.6M
Bridging the Gap between Genomics and Clinical Outcomes in CHDUM1HL128711 · NHLBI · UNIVERSITY OF UTAH · PI TRISTANI-FIROUZI, MARTIN, YANDELL, MARK DOUGLAS · 2015 to 2019
$2.0M
NCATS NIH HHS UL1 TR002538NHLBI NIH HHS T32 HL007576NHLBI NIH HHS UM1 HL128711NIDDK NIH HHS T32 DK110966
6 · The paper itself

Abstract

Understanding the conditionally-dependent clinical variables that drive cardiovascular health outcomes is a major challenge for precision medicine. Here, we deploy a recently developed massively scalable comorbidity discovery method called Poisson Binomial based Comorbidity discovery (PBC), to analyze Electronic Health Records (EHRs) from the University of Utah and Primary Children's Hospital (over 1.6 million patients and 77 million visits) for comorbid diagnoses, procedures, and medications. Using explainable Artificial Intelligence (AI) methodologies, we then tease apart the intertwined, conditionally-dependent impacts of comorbid conditions and demography upon cardiovascular health, focusing on the key areas of heart transplant, sinoatrial node dysfunction and various forms of congenital heart disease. The resulting

Identifiers

PMID35373216
PMCPMC8975108
OpenAlexW4226090820

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.