Evidence map›Paper›PMID 35373585›Full record

Trial reportAmerican journal of physiology. Endocrinology and metabolism2022

Dual endothelin receptor antagonism increases resting energy expenditure in people with increased adiposity.

Cassandra C Derella, Anson M Blanks, Andy Nguyen, Jacob Looney, Matthew A Tucker, Jinhee Jeong, Paula Rodriguez-Miguelez, Jeffrey Thomas, Matthew Lyon, David M Pollock and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Endothelin-1 as a novel target for the prevention of metabolic dysfunction with intermittent hypoxia in male participants.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Cassandra C DerellaDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.ORCID 0000-0003-1649-9347
Anson M BlanksDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.ORCID 0000-0002-5366-8376
Andy NguyenMedical College of Georgia, Augusta University, Augusta, Georgia.
Jacob LooneyDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.
Matthew A TuckerDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.
Jinhee JeongDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.ORCID 0000-0002-8748-8429
Paula Rodriguez-MiguelezDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.ORCID 0000-0003-3582-4483
Jeffrey ThomasDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.
Matthew LyonMedical College of Georgia, Augusta University, Augusta, Georgia.
David M PollockCardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Ryan A HarrisDepartment of Medicine, Georgia Prevention Institute, Augusta University, Augusta, Georgia.ORCID 0000-0002-8826-681X
Augusta University · USUniversity of Alabama at Birmingham · USUniversity of Ulster · GBVirginia Commonwealth University · US

Funding

Vascular and renal responses to stressP01HL069999 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI GEORGE, VARGHESE · 2002 to 2018
$31.1M
NHLBI NIH HHS P01 HL069999
6 · The paper itself

Abstract

Increased adiposity is associated with dysregulation of the endothelin system, both of which increase the risk of cardiovascular disease (CVD). Preclinical data indicate that endothelin dysregulation also reduces resting energy expenditure (REE). The objective was to test the hypothesis that endothelin receptor antagonism will increase REE in people with obesity compared with healthy weight individuals. Using a double blind, placebo-controlled, crossover design, 32 participants [healthy weight (HW):

Indexed as

AdiposityCardiovascular DiseasesAdultBasal MetabolismBosentanCalorimetry, IndirectEndothelinsEnergy MetabolismHumansObesityOverweightReceptors, EndothelinYoung AdultBosentanEndothelinsReceptors, Endothelinbosentanendothelinenergy expenditureobesity

Identifiers

PMID35373585
PMCPMC9126219
OpenAlexW4226027235

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.