Evidence map›Paper›PMID 35379913›Full record

ArticleBone marrow transplantation2022

Genome-wide variants and polygenic risk scores for cognitive impairment following blood or marrow transplantation.

Noha Sharafeldin, Jianqing Zhang, Purnima Singh, Alysia Bosworth, Yanjun Chen, Sunita K Patel, Xuexia Wang, Liton Francisco, Stephen J Forman, F Lennie Wong and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone marrow transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Noha SharafeldinInstitute for Cancer Outcomes and Survivorship, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. nsharafeldin@uabmc.edu.ORCID http://orcid.org/0000-0001-8835-8899
Jianqing ZhangDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Purnima SinghInstitute for Cancer Outcomes and Survivorship, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Alysia BosworthPopulation Sciences, City of Hope, Duarte, CA, USA.
Yanjun ChenInstitute for Cancer Outcomes and Survivorship, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Sunita K PatelPopulation Sciences, City of Hope, Duarte, CA, USA.
Xuexia WangDepartment of Mathematics, University of North Texas, Denton, TX, USA.
Liton FranciscoInstitute for Cancer Outcomes and Survivorship, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Stephen J FormanHematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0002-2803-4152
F Lennie WongPopulation Sciences, City of Hope, Duarte, CA, USA.
Akinyemi I OjesinaDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Smita BhatiaInstitute for Cancer Outcomes and Survivorship, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. smitabhatia@uabmc.edu.ORCID http://orcid.org/0000-0002-7755-5683
University of Alabama at Birmingham · USCity of Hope · USUniversity of North Texas · US

Funding

NCI NIH HHS R35 CA220502NCI NIH HHS U01 CA213140
6 · The paper itself

Abstract

Cognitive impairment is prevalent in blood or marrow transplantation (BMT) recipients, albeit with inter-individual variability. We conducted a genome-wide association study of objective cognitive function assessed longitudinally in 239 adult BMT recipients for discovery and replicated in an independent cohort of 540 BMT survivors. Weighted genome-wide polygenic risk scores (PRS) were constructed using linkage disequilibrium pruned significant SNPs. Forty-four genome-wide significant SNPs were identified using additive (n = 3); codominant (n = 20) and genotype models (n = 21). Each additional copy of a risk allele was associated with a 0.28-point (p = 1.07 × 10

Indexed as

Cognitive DysfunctionGenome-Wide Association StudyAdultBone MarrowGenetic Predisposition to DiseaseHumansMultifactorial InheritancePolymorphism, Single NucleotideRisk Factors

Identifiers

PMID35379913
PMCPMC9233077
OpenAlexW4224275397

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.