Evidence map›Paper›PMID 35380386›Full record

ArticleHepatology international2022

Aspirin improves transplant-free survival after TIPS implantation in patients with refractory ascites: a retrospective multicentre cohort study.

Leon Louis Seifert, Philipp Schindler, Lukas Sturm, Wenyi Gu, Quentin Edward Seifert, Jan Frederic Weller, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Martin Schoster and 11 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hepatology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 1 country.

Leon Louis SeifertMedical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany. leonlouis.seifert@ukmuenster.de.ORCID http://orcid.org/0000-0002-0089-7669
Philipp SchindlerClinic for Radiology, University Hospital Muenster, 48149, Muenster, Germany.
Lukas SturmDepartment of Medicine II, Medical Center University of Freiburg, University of Freiburg, 79106, Freiburg, Germany.
Wenyi GuDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596, Frankfurt, Germany.
Quentin Edward SeifertGeorg-August University of Goettingen, 37073, Goettingen, Germany.
Jan Frederic WellerDepartment of Hematology, University Hospital Tuebingen, 72076, Tuebingen, Germany.
Christian JansenDepartment of Internal Medicine I, University Hospital Bonn, 53127, Bonn, Germany.
Michael PraktiknjoDepartment of Internal Medicine I, University Hospital Bonn, 53127, Bonn, Germany.
Carsten MeyerDepartment of Radiology, University Hospital Bonn, 53127, Bonn, Germany.
Martin SchosterMedical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany.
Christian WilmsMedical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany.
Miriam MaschmeierMedical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany.
Hartmut H SchmidtMedical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany.
Max MasthoffClinic for Radiology, University Hospital Muenster, 48149, Muenster, Germany.
Michael KöhlerClinic for Radiology, University Hospital Muenster, 48149, Muenster, Germany.
Michael SchultheissDepartment of Medicine II, Medical Center University of Freiburg, University of Freiburg, 79106, Freiburg, Germany.
Jan Patrick HuberDepartment of Medicine II, Medical Center University of Freiburg, University of Freiburg, 79106, Freiburg, Germany.
Dominik BettingerDepartment of Medicine II, Medical Center University of Freiburg, University of Freiburg, 79106, Freiburg, Germany.
Jonel TrebickaDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596, Frankfurt, Germany.
Moritz WildgruberClinic for Radiology, University Hospital Muenster, 48149, Muenster, Germany.
Hauke HeinzowMedical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany.
University Hospital Münster · DEUniversity of Freiburg · DEUniversity Hospital Bonn · DEGoethe University Frankfurt · DEKrankenhaus der Barmherzigen Brüder Trier · DELMU Klinikum · DEUniversity of Göttingen · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsTransjugular intrahepatic portosystemic shunt (TIPS) implantation is an established procedure to treat portal hypertension. Impact of administration of aspirin on transplant-free survival after TIPS remains unknown.

methodsA multicenter retrospective analysis including patients with TIPS implantation between 2011 and 2018 at three tertiary German Liver Centers was performed. N = 583 patients were included. Survival analysis was performed in a matched cohort after propensity score matching. Patients were grouped according to whether aspirin was (PSM-aspirin-cohort) or was not (PSM-no-aspirin-cohort) administered after TIPS. Primary endpoint of the study was transplant-free survival at 12 months after TIPS.

resultsAspirin improved transplant-free survival 12 months after TIPS with 90.7% transplant-free survival compared to 80.0% (p = 0.001) after PSM. Separated by TIPS indication, aspirin did improve transplant-free survival in patients with refractory ascites significantly (89.6% vs. 70.6% transplant-free survival, p < 0.001), while no significant effect was observed in patients with refractory variceal bleeding (91.1% vs. 92.2% transplant-free survival, p = 0.797).

conclusionThis retrospective multicenter study provides first data indicating a beneficial effect of aspirin on transplant-free survival after TIPS implantation in patients with refractory ascites.

Indexed as

Esophageal and Gastric VaricesPortasystemic Shunt, Transjugular IntrahepaticAscitesAspirinCohort StudiesGastrointestinal HemorrhageHumansLiver CirrhosisRetrospective StudiesTreatment OutcomeAspirinAscitesAspirinComplications of liver cirrhosisDecompensated liver cirrhosisHepatic decompensationLiver transplantationPortal hypertensionPropensity score matchingThrombocyte aggregation inhibitionTransjugular intrahepatic portosystemic shuntVariceal bleeding

Identifiers

PMID35380386
PMCPMC9174324
OpenAlexW4226151632

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.