Evidence map›Paper›PMID 35383530›Full record

ArticleAutophagy2022

Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases.

Iris Grosjean, Barnabé Roméo, Marie-Angela Domdom, Amine Belaid, Grégoire D'Andréa, Nicolas Guillot, Romain K Gherardi, Jocelyn Gal, Gérard Milano, Charles Hugo Marquette and 9 more

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
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  6. Observational
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  9. Article
  10. Article
  11. Review
  12. Biological Basis of Cell Trafficking: A General Overview.Journal of inherited metabolic disease · 2025
    Review
  13. The danger theory of immunity revisited.Nature reviews. Immunology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Autophagy-Related GeneJournal of clinical medicine · 2024
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 4 countries.

Iris GrosjeanUniversity Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Centre Antoine Lacassagne, France.ORCID 0000-0002-1017-8270
Barnabé RoméoUniversity Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Centre Antoine Lacassagne, France.ORCID 0000-0001-6011-4868
Marie-Angela DomdomUniversity Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Centre Antoine Lacassagne, France.ORCID 0000-0002-9896-6270
Amine BelaidUniversité Côte d'Azur (UCA), INSERM U1065, C3M, Team 5, F-06204, France.ORCID 0000-0001-6661-6762
Grégoire D'AndréaUniversity Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Centre Antoine Lacassagne, France.ORCID 0000-0003-3838-513X
Nicolas GuillotUniversity Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Centre Antoine Lacassagne, France.ORCID 0000-0002-2989-2511
Romain K GherardiINSERM U955 Team Relais, Faculty of Health, Paris Est University, France.ORCID 0000-0001-6558-0366
Jocelyn GalUniversity Côte d'Azur, Centre Antoine Lacassagne, Epidemiology and Biostatistics Department, Nice, France.ORCID 0000-0002-1802-118X
Gérard MilanoUniversité Côte d'Azur, Centre Antoine Lacassagne, UPR7497, Nice, France.ORCID 0000-0003-2478-0040
Charles Hugo MarquetteUniversity Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Centre Antoine Lacassagne, France.ORCID 0000-0002-0846-9941
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-4486-7496
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4507-329X
Younghun HanInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5048-8479
Patrick BrestUniversity Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Centre Antoine Lacassagne, France.ORCID 0000-0002-1252-4747
Martin Von BergenHelmholtz Centre for Environmental Research GmbH - UFZ, Dep. of Molecular Systems Biology; University of Leipzig, Faculty of Life Sciences, Institute of Biochemistry, Leipzig, Germany.ORCID 0000-0003-2732-2977
Daniel J KlionskyUniversity of Michigan, Life Sciences Institute, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-7828-8118
Christopher I AmosInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-8540-7023
Paul HofmanUniversity Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Centre Antoine Lacassagne, France.ORCID 0000-0003-0431-9353
Baharia MograbiUniversity Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Centre Antoine Lacassagne, France.ORCID 0000-0002-1025-3429
Centre National de la Recherche Scientifique · FRBaylor College of Medicine · USInserm · FRCentre Antoine Lacassagne · FRHelmholtz Centre for Environmental Research · DENational Institutes of Health · USUniversité Côte d'Azur · FRUniversity of Michigan · USUniversity of Toronto · CA

Funding

The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

At a time when complex diseases affect globally 280 million people and claim 14 million lives every year, there is an urgent need to rapidly increase our knowledge into their underlying etiologies. Though critical in identifying the people at risk, the causal environmental factors (microbiome and/or pollutants) and the affected pathophysiological mechanisms are not well understood. Herein, we consider the variations of autophagy-related (

Indexed as

Amyotrophic Lateral SclerosisCarcinoma, HepatocellularCarcinoma, Non-Small-Cell LungFrontotemporal DementiaHead and Neck NeoplasmsLiver NeoplasmsLung NeoplasmsAutophagyGenome-Wide Association StudyHumansPolymorphism, GeneticPrecision MedicineSquamous Cell Carcinoma of Head and NeckAutophagycancersdiseaseseQTLpollutants/exposomicspolymorphismprognosisrisksusceptibilitytheragnosis

Identifiers

PMID35383530
PMCPMC9629091
OpenAlexW4226094138

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.