Evidence map›Paper›PMID 35384697›Full record

ArticlemBio2022

Bimodal Expression Patterns, and Not Viral Burst Sizes, Predict the Effects of Vpr on HIV-1 Proviral Populations in Jurkat Cells.

Edmond Atindaana, Abena Kissi-Twum, Sarah Emery, Cleo Burnett, Jake Pitcher, Myra Visser, Jeffrey M Kidd, Alice Telesnitsky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Manipulation of the cell cycle by HIV-1.Biochemical Society transactions · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Edmond AtindaanaDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Abena Kissi-TwumWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Greater Accra Region, Ghana.
Sarah EmeryHuman Genetics, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Cleo BurnettDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Jake PitcherDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Myra VisserDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Jeffrey M KiddHuman Genetics, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Alice TelesnitskyDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.ORCID 0000-0001-9878-5931
University of Michigan · USUniversity of Ghana · GH

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
High throughput analysis of latency/reactivation with barcoded provirusesR33AI116190 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHANG, CHEONG-HEE, KIDD, JEFFREY M · 2016 to 2018
$1.4M
NCI NIH HHS P30 CA046592NIAID NIH HHS R33 AI116190
6 · The paper itself

Abstract

Integration site landscapes, clonal dynamics, and latency reversal with or without

Indexed as

HIV-1HIV SeropositivityHumansJurkat CellsProvirusesvpr Gene Products, Human Immunodeficiency Virusvpr Gene Products, Human Immunodeficiency VirusHIV-1 expression propertiesHIV-1 persistenceHIV-1 population dynamicsintegration siteslatency reactivationlatency-reversing agentsLRAs

Identifiers

PMID35384697
PMCPMC9040753
OpenAlexW4224937183

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.