Evidence map›Paper›PMID 35386433›Full record

ReviewCurrent genomics2021

A Brief Review of circRNA Biogenesis, Detection, and Function.

Ying Liang, Niannian Liu, Le Yang, Jianjun Tang, Yinglong Wang, Meng Mei

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 57 citations in OpenAlex.

  1. Circular RNAs in ferroptosis regulation and tumor progression of gynecological and breast cancers: molecular mechanisms and therapeutic potential.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  14. Circular RNAs in Organ Fibrosis.Advances in experimental medicine and biology · 2025
    Review
  15. Article
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  17. Circular RNAs in Heart Diseases.Advances in experimental medicine and biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ying LiangCollege of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, China.
Niannian LiuCollege of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, China.
Le YangCollege of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, China.
Jianjun TangCollege of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, China.
Yinglong WangCollege of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, China.
Meng MeiDepartment of Basic teaching, Jiangxi Business School, Nanchang, China.
Jiangxi Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC). Its formation depends on complementary intron sequences on both sides of the circularized sequence. CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulator or potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain. In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. We also summarize methods using sequence feature and RNA next-generation sequencing data for circRNA prediction. Finally, we discuss the state of the research on circRNA in diseases, which will bring new contributions to future disease treatments.

Indexed as

alternative splicingbiomarkerCircRNAcomplementary introndiseasemiRNA sponge

Identifiers

PMID35386433
PMCPMC8905635
OpenAlexW3141771520

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.