Evidence map›Paper›PMID 35388548›Full record

ArticleJournal of clinical laboratory analysis2022

Analysis of anti-apoptotic PVT1 oncogene and apoptosis-related proteins (p53, Bcl2, PD-1, and PD-L1) expression in thyroid carcinoma.

Afaf T Ibrahiem, Amin K Makhdoom, Khalid S Alanazi, Abdulaziz M Alanazi, Abdulaziz M Mukhlef, Saad H Elshafey, Eman A Toraih, Manal S Fawzy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Afaf T IbrahiemDepartment of Pathology, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.ORCID https://orcid.org/0000-0002-8636-0220
Amin K MakhdoomFaculty of Medicine, Northern Border University, Arar, Saudi Arabia.ORCID https://orcid.org/0000-0001-5434-6988
Khalid S AlanaziFaculty of Medicine, Northern Border University, Arar, Saudi Arabia.ORCID https://orcid.org/0000-0002-5169-2524
Abdulaziz M AlanaziFaculty of Medicine, Northern Border University, Arar, Saudi Arabia.ORCID https://orcid.org/0000-0002-0255-5945
Abdulaziz M MukhlefFaculty of Medicine, Northern Border University, Arar, Saudi Arabia.ORCID https://orcid.org/0000-0001-6409-7153
Saad H ElshafeyDepartment of Anatomy, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Eman A ToraihDivision of Endocrine and Oncologic Surgery, Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.ORCID https://orcid.org/0000-0001-9267-3787
Manal S FawzyDepartment of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.ORCID https://orcid.org/0000-0003-1252-8403
Northern Border University · SASuez Canal University · EG

Funding

Deanship of Scientific Research, Northern Border University, Arar, Saudi Arabia 7798-MED-2018-3-9-F
6 · The paper itself

Abstract

backgroundAn aberrant expression of long non-coding RNA PVT1 has been associated with apoptosis in various cancer types. We aimed to explore the PVT1 and four apoptosis-related proteins (p53, Bcl2, and PD-1/PD-L1) signature in thyroid cancer (TC).

methodsThe PVT1 expression level was measured in 64 FFPE TC paired samples by real-time quantitative PCR. Overall and stratified analyses by different clinicopathological features were done. The apoptotic proteins were evaluated by immunohistochemistry staining.

resultsOverall analysis showed significant PVT1upregulation in TC tissues (p < 0.001). Similarly, subgroup analysis by BRAF

conclusionOur results confirm the upregulation of PVT1 in TC. The apoptosis-related proteins (p53, Bcl2, and PD-1/PD-L1) showed different prognostic utility in TC patients; in particular, low p53 and high PD-L1 expressions associated with low survival times. Further large-scale and mechanistic studies are warranted.

Indexed as

Hepatitis CThyroid NeoplasmsApoptosisB7-H1 AntigenBiomarkers, TumorHumansOncogenesProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53B7-H1 AntigenBCL2 protein, humanBiomarkers, TumorProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53Bcl2immunohistochemistryP53papillary thyroid cancerPD-1PD-L1PVT1real-time PCR

Identifiers

PMID35388548
PMCPMC9102754
OpenAlexW4226278911

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.