Evidence map›Paper›PMID 35388695›Full record

ArticleThe journal of physical chemistry. B2022

Peptide Permeation across a Phosphocholine Membrane: An Atomically Detailed Mechanism Determined through Simulations and Supported by Experimentation.

Alfredo E Cardenas, Chad I Drexler, Rachel Nechushtai, Ron Mittler, Assaf Friedler, Lauren J Webb, Ron Elber

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

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  9. Perspective: Path Sampling Methods Applied to Enzymatic Catalysis.Journal of chemical theory and computation · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alfredo E CardenasInstitute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Texas 78712, United States.
Chad I DrexlerDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-9989-968X
Rachel NechushtaiThe Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat-Ram, Jerusalem 91904, Israel.
Ron MittlerThe Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center, University of Missouri, 1201 Rollins Street, Columbia, Missouri 65201, United States.
Assaf FriedlerThe Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat-Ram, Jerusalem 91904, Israel.ORCID 0000-0003-1592-1278
Lauren J WebbDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-9999-5500
Ron ElberInstitute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-7849-415X
The University of Texas at Austin · USHebrew University of Jerusalem · ILUniversity of Missouri · US

Funding

LONG TIME DYNAMICS OF BIOMOLECULESR01GM059796 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ELBER, RON · 2000 to 2021
$5.7M
Modeling Membrane Dynamics and PermeationR01GM111364 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI CARDENAS, ALFREDO, ELBER, RON · 2016 to 2023
$2.5M
NIGMS NIH HHS R01 GM059796NIGMS NIH HHS R01 GM111364
6 · The paper itself

Abstract

Cell-penetrating peptides (CPPs) facilitate translocation across biological membranes and are of significant biological and medical interest. Several CPPs can permeate into specific cells and organelles. We examine the incorporation and translocation of a novel anticancer CPP in a dioleoylphosphatidylcholine (DOPC) lipid bilayer membrane. The peptide, NAF-1

Indexed as

Cell-Penetrating PeptidesPhosphorylcholineKineticsLipid BilayersThermodynamicsCell-Penetrating PeptidesLipid BilayersPhosphorylcholine

Identifiers

PMID35388695
PMCPMC9074375
OpenAlexW4224257894

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.