ArticleThe Biochemical journal1986
Active transport of myo-inositol in rat pancreatic islets.
Article in The Biochemical journal, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Correlation between tooth decay and insulin resistance in normal weight males prompts a role for myo-inositol as a regenerative factor in dentistry and oral surgery: a feasibility study.Frontiers in bioengineering and biotechnology · 2024Article
- Effect of osmolality and myo-inositol deprivation on the transport properties of myo-inositol in primary astrocyte cultures.Neurochemical research · 1997Article
- Regulation of myo-inositol transport during the growth and differentiation of thyrocytes: a link with thyroid-stimulating hormone-induced phospholipase A2 activity.The Biochemical journal · 1995Article
- Mitogen-activated protein kinase and its activator are regulated by hypertonic stress in Madin-Darby canine kidney cells.The Journal of clinical investigation · 1994Article
- Osmotic regulation of myo-inositol uptake in primary astrocyte cultures.Neurochemical research · 1994Article
- myo-inositol transport and metabolism in fetal-bovine aortic endothelial cells.The Biochemical journal · 1993Article
- The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells.The Biochemical journal · 1993Article
- Effects of fluorinated inositols on the proliferation of Swiss 3T3 fibroblasts.The Biochemical journal · 1993Article
- In vivo use of neutral radiolabelled molecular probes to evaluate blood-ocular barrier integrity in normal and streptozotocin-diabetic rats.Diabetologia · 1991Article
- Osmoregulatory changes in myo-inositol transport by renal cells.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Changes in extracellular calcium within the physiological range influence receptor-mediated inositol phosphate responses in brain and tracheal smooth muscle slices.Naunyn-Schmiedeberg's archives of pharmacology · 1989Article
- Uptake and metabolism of myo-inositol by L1210 leukaemia cells.The Biochemical journal · 1988Article
- Characterization of glucose transport in an insulin-secreting cell line.The Biochemical journal · 1987Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
myo-Inositol transport by isolated pancreatic islets was measured with a dual isotope technique. Uptake was saturable with a half-maximal response at approx. 75 microM. With 50 microM-inositol, uptake was linear for at least 2 h during which time the free intracellular concentration rose to double that of the incubation medium. Inositol transport is therefore active and probably energized by electrogenic co-transport of Na+ down its concentration gradient as uptake was inhibited by ouabain, Na+ removal or depolarizing K+ concentrations. Inositol transport was abolished by cytochalasin B which binds to hexose carriers, but not by carbamoylcholine or Li+ which respectively stimulate or inhibit phosphoinositide turnover. Uptake of inositol was not affected by 3-O-methylglucose or L-glucose (both 100 mM) nor by physiological concentrations of D-glucose. The results suggest that most intracellular inositol in pancreatic islets would be derived from the extracellular medium. Since the transport mechanism is distinct from that of glucose, inositol uptake would not be inhibited during periods of hyperglycaemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.