Evidence map›Paper›PMID 35391614›Full record

ArticleAngiogenesis2022

NRAS

Elisa Boscolo, Patricia Pastura, Sandra Schrenk, Jillian Goines, Rachael Kang, Devin Pillis, Punam Malik, Timothy D Le Cras

Abstract read
In one paragraph

Article in Angiogenesis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. Review
  3. Sirolimus outperforms alpelisib in models ofBlood vessels, thrombosis & hemostasis · 2026
    Article
  4. RAS Inhibitor RMC-7977 Blocks Vascular Overgrowth of NRASJournal of cellular and molecular medicine · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Positive feedback loop between NRASBiochemical and biophysical research communications · 2025
    Article
  12. Lyve1-Driven NrasPediatric blood & cancer · 2025
    Article
  13. NRASPediatric blood & cancer · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elisa BoscoloDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. elisa.boscolo@cchmc.org.ORCID 0000-0002-6996-0419
Patricia Pastura *Division of Pulmonary Biology, Cincinnati Children's Hospital, Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA.
Sandra Schrenk *Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Jillian GoinesDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Rachael KangDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Devin PillisDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Punam MalikDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Timothy D Le CrasDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. tim.lecras@cchmc.org.ORCID 0000-0001-8538-2703

Funding

Venous Malformations (VM): A Murine Model to Identify Therapies to Target AberranR01HL117952 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BOSCOLO, ELISA · 2013 to 2025
$4.9M
Pathogenesis and Treatment of Kaposiform LymphangiomatosisR01HL156866 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TIMOTHY DAVID LE CRAS · 2022 to 2026
$3.3M
NHLBI NIH HHS R01 HL117952NHLBI NIH HHS R01 HL156866NIH HHS R01 HL156866
6 · The paper itself

Abstract

Somatic mutations in NRAS drive the pathogenesis of melanoma and other cancers but their role in vascular anomalies and specifically human endothelial cells is unclear. The goals of this study were to determine whether the somatic-activating NRAS

Indexed as

GTP PhosphohydrolasesMembrane ProteinsVascular MalformationsAnimalsEndothelial CellsHumansMiceMice, NudeMutationGTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanKaposiform lymphangiomatosisLymphatic anomalyRASopathiesVascular AnomalyVascular Malformation

Identifiers

PMID35391614
PMCPMC9631803

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.