Evidence map›Paper›PMID 35392409›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Blast Waves Cause Immune System Dysfunction and Transient Bone Marrow Failure in a Mouse Model.

Elke S Bergmann-Leitner, Alexander G Bobrov, Jessica S Bolton, Michael D Rouse, Lanier Heyburn, Radmila Pavlovic, Brittany I Garry, Yonas Alamneh, Joseph Long, Brett Swierczewski and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Elke S Bergmann-LeitnerBiologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Alexander G BobrovWound Infections Department, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Jessica S BoltonBiologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Michael D RouseWound Infections Department, Naval Research Medical Center, Silver Spring, MD, United States.
Lanier HeyburnBlast Induced Neurotrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Radmila PavlovicWound Infections Department, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Brittany I GarryWound Infections Department, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Yonas AlamnehWound Infections Department, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Joseph LongBlast Induced Neurotrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Brett SwierczewskiBacterial Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Stuart TynerMilitary Infectious Diseases Research Program, Frederick, MD, United States.
Derese GetnetWound Infections Department, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Venkatasivasai S SajjaBlast Induced Neurotrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Vlado AntonicWound Infections Department, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Walter Reed Army Institute of Research · USJackson Foundation · USUnited States Army Medical Research Institute of Infectious Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Explosive devices, either conventional or improvised, are common sources of injuries during combat, civil unrest, and terror attacks, resulting in trauma from exposure to blast. A blast wave (BW), a near-instantaneous rise in pressure followed by a negative pressure, propagates through the body in milliseconds and can affect physiology for days/months after exposure. Epidemiological data show that blast-related casualties result in significantly higher susceptibility to wound infections, suggesting long-lasting immune modulatory effects from blast exposure. The mechanisms involved in BW-induced immune changes are poorly understood. We evaluated the effects of BW on the immune system using an established murine model. Animals were exposed to BWs (using an Advanced Blast Simulator), followed by longitudinally sampling for 14 days. Blood, bone marrow, and spleen were analyzed for changes in the 1) complete blood count (CBC), and 2) composition of bone marrow cells (BMC) and splenocytes, and 3) concentrations of systemic cytokines/chemokines. Our data demonstrate that BW results in transient bone marrow failure and long-term changes in the frequency and profile of progenitor cell populations. Viability progressively decreased in hematopoietic stem cells and pluripotent progenitor cells. Significant decrease of CD4

Indexed as

blast wavebone marrowcytokinehematopoietic stem cellsimmune responselong term effectsprogenitor cellsspleen

Identifiers

PMID35392409
PMCPMC8980552
OpenAlexW4220867479

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.