Evidence map›Paper›PMID 35397496›Full record

ArticleCellular & molecular biology letters2022

Anti-cancer peptide-based therapeutic strategies in solid tumors.

Mohsen Karami Fath, Kimiya Babakhaniyan, Maryam Zokaei, Azadeh Yaghoubian, Sadaf Akbari, Mahdieh Khorsandi, Asma Soofi, Mohsen Nabi-Afjadi, Hamidreza Zalpoor, Fateme Jalalifar and 3 more

Open access · goldAbstract readLetter
In one paragraph

Article in Cellular & molecular biology letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 150 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
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  6. Review
  7. Extraction of pH-Dependent DNA-Binding Anti-Tumoral Peptides fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. How Key in vivo Models Can Advance Anticancer Nanotherapeutics.International journal of nanomedicine · 2026
    Review
  12. Article
  13. Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis.Angewandte Chemie (International ed. in English) · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 3 countries.

Mohsen Karami FathDepartment of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
Kimiya BabakhaniyanDepartment of Medical Surgical Nursing, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
Maryam ZokaeiDepartment of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology/National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Azadeh YaghoubianDepartment of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Sadaf AkbariFaculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahdieh KhorsandiDepartment of Biotechnology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Asma SoofiDepartment of Physical Chemistry, School of Chemistry, College of Sciences, University of Tehran, Tehran, Iran.
Mohsen Nabi-AfjadiDepartment of Biochemistry, Faculty of biological science, Tarbiat Modares University, Tehran, Iran.
Hamidreza ZalpoorAmerican Association of Kidney Patients, Tampa, FL, USA.
Fateme JalalifarSchool of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.
Ali AzargoonjahromiShiraz University of Medical Sciences, Shiraz, Iran.
Zahra PayandehDepartment Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden. zpayandeh58@yahoo.com.ORCID http://orcid.org/0000-0003-2565-8231
Armina Alagheband BahramiDepartment of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. aarminaa@gmail.com.
Mashhad University of Medical Sciences · IRShiraz University of Medical Sciences · IRIran University of Medical Sciences · IRIslamic Azad University Central Tehran Branch · IRIslamic Azad University, Tehran · IRKarolinska Institutet · SEKharazmi University · IRShahid Beheshti University of Medical Sciences · IRTarbiat Modares University · IRUniversity of Jiroft · IRUniversity of Tehran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to deliver drugs or active agents selectively.

resultIntroducing beneficial therapeutic approaches, such as therapeutic peptides and their varied methods of action against tumor cells, can aid researchers in the discovery of novel peptides for cancer treatment. The biomedical applications of therapeutic peptides are highly interesting. These peptides, owing to their high selectivity, specificity, small dimensions, high biocompatibility, and easy modification, provide good opportunities for targeted drug delivery. In recent years, peptides have shown considerable promise as therapeutics or targeting ligands in cancer research and nanotechnology.

conclusionThis study reviews a variety of therapeutic peptides and targeting ligands in cancer therapy. Initially, three types of tumor-homing and cell-penetrating peptides (CPPs) are described, and then their applications in breast, glioma, colorectal, and melanoma cancer research are discussed.

Indexed as

Antineoplastic AgentsCell-Penetrating PeptidesGliomaNeoplasmsDrug Delivery SystemsHumansLigandsAntineoplastic AgentsCell-Penetrating PeptidesLigandsDrug deliveryPeptide-based strategiesTargeted deliveryTumor-homing peptides

Identifiers

PMID35397496
PMCPMC8994312
OpenAlexW4223433895

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.