Evidence map›Paper›PMID 35400284›Full record

ArticleBioengineered2022

Matrine Combined with Mammalian Target of Rapamycin Inhibitor Enhances Anti-Tumor Efficacy of dendritic cell Vaccines in hepatocellular carcinoma.

Ning Zhou, Sheng Li, Fan Zhang, Cong Chen, Yumin Li

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ning ZhouDepartment of Gastroenterology, The First People's Hospital of Lanzhou City, Lanzhou Gansu, China.
Sheng LiDepartment of Gastroenterology, The First People's Hospital of Lanzhou City, Lanzhou Gansu, China.
Fan ZhangKey Laboratory of Digestive System Tumors of Gansu Province, Lanzhou Gansu, China.
Cong ChenKey Laboratory of Digestive System Tumors of Gansu Province, Lanzhou Gansu, China.
Yumin LiKey Laboratory of Digestive System Tumors of Gansu Province, Lanzhou Gansu, China.
First Hospital of Lanzhou University · CNLanzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs), as the most important antigen-presenting cells, play a crucial role in T cell activation. The latest research showed that inhibition of the mammalian target of rapamycin (mTOR) could enhance DCs maturation, promoting antigen presentation. Matrine has been identified as one of the key alkaloids isolated from the roots of

Indexed as

AlkaloidsCarcinoma, HepatocellularLiver NeoplasmsCytokinesDendritic CellsHumansLipopolysaccharidesMatrinesQuinolizinesSirolimusTOR Serine-Threonine KinasesAlkaloidsCytokinesLipopolysaccharidesMatrinesQuinolizinesSirolimusTOR Serine-Threonine KinasesCTLdendritic cellsHuh7 cellsMatrinemTOR inhibitornude micevaccine

Identifiers

PMID35400284
PMCPMC9161910
OpenAlexW4223507404

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.